The microculture-kinetic (MiCK) assay: The role of a drug-induced apoptosis assay in drug development and clinical care

Linda Bosserman, Franklyn Prendergast, Roy Herbst, Martin Fleisher, Emery Salom, Steven Strickland, Anastasios Raptis, Allan Hallquist, Mathieu Perree, Swapnil Rajurkar, Misagh Karimi, Karl Rogers, Dirk Davidson, Carl Willis, Manuel Penalver, Howard Homesley, Matthew Burrell, Audrey Garrett, James Rutledge, Michael ChernickCary A. Presant

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

A drug-induced apoptosis assay, termed the microculture-kinetic (MiCK) assay, has been developed. Blinded clinical trials have shown higher response rates and longer survival in groups of patients with acute myelocytic leukemia and epithelial ovarian cancer who have been treated with drugs that show high apoptosis in the MiCK assay. Unblinded clinical trials in multiple tumor types have shown that the assay will be used frequently by clinicians to determine treatment, and when used, results in higher response rates, longer times to relapse, and longer survivals. Model economic analyses suggest possible cost savings in clinical use based on increased generic drug use and single-agent substitution for combination therapies. Two initial studies with drugs in development are promising. The assay may help reduce costs and speed time to drug approval. Correlative studies with molecular biomarkers are planned. This assay may have a role both in personalized clinical therapy and in more efficient drug development.

Original languageEnglish (US)
Pages (from-to)3901-3905
Number of pages5
JournalCancer research
Volume72
Issue number16
DOIs
StatePublished - Aug 15 2012

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The microculture-kinetic (MiCK) assay: The role of a drug-induced apoptosis assay in drug development and clinical care'. Together they form a unique fingerprint.

  • Cite this

    Bosserman, L., Prendergast, F., Herbst, R., Fleisher, M., Salom, E., Strickland, S., Raptis, A., Hallquist, A., Perree, M., Rajurkar, S., Karimi, M., Rogers, K., Davidson, D., Willis, C., Penalver, M., Homesley, H., Burrell, M., Garrett, A., Rutledge, J., ... Presant, C. A. (2012). The microculture-kinetic (MiCK) assay: The role of a drug-induced apoptosis assay in drug development and clinical care. Cancer research, 72(16), 3901-3905. https://doi.org/10.1158/0008-5472.CAN-12-0681