The Microbiome in Crohn's Disease. Role in Pathogenesis and Role of Microbiome Replacement Therapies

Sahil Khanna, Laura E. H. Raffals

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Individuals with a genetic predisposition to Crohn disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of Crohn disease. Decrease in global gut microbial diversity and specific bacterial alterations have been implicated in Crohn disease. Advances in sequencing techniques and bioinformatics and correlation with host genetics continue to improve insight into the structure and function of the microbial community and interactions with the host immune system. This article summarizes the existing literature on the role of the gut microbiome and its manipulation in development and management of Crohn disease.

Original languageEnglish (US)
JournalGastroenterology Clinics of North America
DOIs
StateAccepted/In press - 2017

Keywords

  • Crohn's disease
  • Fecal microbiota transplantation
  • Gut microbiota
  • Inflammatory bowel disease
  • Microbiome
  • Pathogenesis
  • Probiotics

ASJC Scopus subject areas

  • Gastroenterology

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