The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features

Jeffrey N. Katz; Christine E. Chaisson; Brian Cole; Ali Guermazi; David J. Hunter; Morgan Jones; Bruce A. Levy; Lisa A. Mandl; Scott Martin; Robert G. Marx; Clare Safran-Norton; Frank W. Roemer; Debra Skoniecki; Daniel H. Solomon; Kurt P. Spindler; John Wright; Rick W. Wright; Elena Losina

doi:10.1016/j.cct.2012.08.010

The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features

Jeffrey N. Katz, Christine E. Chaisson, Brian Cole, Ali Guermazi, David J. Hunter, Morgan Jones, Bruce A. Levy, Lisa A. Mandl, Scott Martin, Robert G. Marx, Clare Safran-Norton, Frank W. Roemer, Debra Skoniecki, Daniel H. Solomon, Kurt P. Spindler, John Wright, Rick W. Wright, Elena Losina

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled trial (RCT) designed to establish the efficacy of arthroscopic partial meniscectomy combined with a standardized physical therapy program as compared with a standardized physical therapy program alone in patients with a symptomatic meniscal tear in the setting of mild to moderate knee osteoarthritic change (OA). The design and execution of a trial that compares surgery with a nonoperative treatment strategy presents distinctive challenges. The goal of this paper is to provide the clinical rationale for MeTeOR and to highlight salient design features, with particular attention to those that present clinical and methodologic challenges.

Original language	English (US)
Pages (from-to)	1189-1196
Number of pages	8
Journal	Contemporary Clinical Trials
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.cct.2012.08.010
State	Published - Nov 2012

Keywords

Arthroscopic partial meniscectomy
Efficacy
Meniscal tear
Methodology
Osteoarthritis
Randomized controlled trial

ASJC Scopus subject areas

Pharmacology (medical)

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10.1016/j.cct.2012.08.010

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Katz, J. N., Chaisson, C. E., Cole, B., Guermazi, A., Hunter, D. J., Jones, M., Levy, B. A., Mandl, L. A., Martin, S., Marx, R. G., Safran-Norton, C., Roemer, F. W., Skoniecki, D., Solomon, D. H., Spindler, K. P., Wright, J., Wright, R. W., & Losina, E. (2012). The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features. Contemporary Clinical Trials, 33(6), 1189-1196. https://doi.org/10.1016/j.cct.2012.08.010

Katz, JN, Chaisson, CE, Cole, B, Guermazi, A, Hunter, DJ, Jones, M, Levy, BA, Mandl, LA, Martin, S, Marx, RG, Safran-Norton, C, Roemer, FW, Skoniecki, D, Solomon, DH, Spindler, KP, Wright, J, Wright, RW & Losina, E 2012, 'The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features', Contemporary Clinical Trials, vol. 33, no. 6, pp. 1189-1196. https://doi.org/10.1016/j.cct.2012.08.010

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The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features

Abstract

Keywords

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