The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus

L. Chatzi, E. Plana, A. Pappas, D. Alegkakis, P. Karakosta, V. Daraki, Maria Vassilaki, C. Tsatsanis, A. Kafatos, A. Koutis, M. Kogevinas

Research output: Contribution to journalArticle

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Abstract

Aim: The objective of the present study was to determine whether or not maternal metabolic syndrome in early pregnancy in women without previous diabetes is associated with the development of gestational diabetes mellitus (GDM). Methods: A total of 508 women from the Rhea study-involving a pregnant cohort in Crete, Greece (2007-2009)-with singleton pregnancies were included in the present analysis. Maternal fasting serum samples were collected and blood pressure measured before gestational week 15. The metabolic syndrome in early pregnancy was defined according to NHLBI/AHA criteria. Pregnant women were screened for GDM between weeks 24 and 28 of gestation, as defined by Carpenter and Coustan criteria. Multivariable log-binomial regression models were used to estimate the effect of the metabolic syndrome in early pregnancy on the risk of GDM, after adjusting for confounding factors. Results: Women with the metabolic syndrome were at high risk of GDM (RR = 3.17; 95% CI: 1.06-9.50). Among the components of the metabolic syndrome, the most significant risk factors were impaired fasting glucose (RR = 4.92; 95% CI: 1.41-17.23) and pre-pregnancy obesity (RR = 2.65; 95% CI: 1.23-5.70). A 10-mmHg rise in systolic and diastolic blood pressure increased the relative risk of GDM by 49% (RR = 1.49; 95% CI: 1.10-2.02) and 34% (RR = 1.34; 95% CI: 1.04-1.73), respectively, whereas a 1-unit increase in pre-pregnancy BMI increased the relative risk of GDM by 6% (RR = 1.06; 95% CI: 1.01-1.12). Conclusion: These findings suggest that women with the metabolic syndrome in early pregnancy have a greater risk of developing GDM.

Original languageEnglish (US)
Pages (from-to)490-494
Number of pages5
JournalDiabetes and Metabolism
Volume35
Issue number6
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Fingerprint

Gestational Diabetes
Pregnancy
Greece
Blood Pressure
Fasting
Rheiformes
Mothers
National Heart, Lung, and Blood Institute (U.S.)
Statistical Models
Pregnant Women
Obesity
Glucose
Serum

Keywords

  • Gestational diabetes
  • Pregnancy
  • The metabolic syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Chatzi, L., Plana, E., Pappas, A., Alegkakis, D., Karakosta, P., Daraki, V., ... Kogevinas, M. (2009). The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus. Diabetes and Metabolism, 35(6), 490-494. https://doi.org/10.1016/j.diabet.2009.07.003

The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus. / Chatzi, L.; Plana, E.; Pappas, A.; Alegkakis, D.; Karakosta, P.; Daraki, V.; Vassilaki, Maria; Tsatsanis, C.; Kafatos, A.; Koutis, A.; Kogevinas, M.

In: Diabetes and Metabolism, Vol. 35, No. 6, 01.12.2009, p. 490-494.

Research output: Contribution to journalArticle

Chatzi, L, Plana, E, Pappas, A, Alegkakis, D, Karakosta, P, Daraki, V, Vassilaki, M, Tsatsanis, C, Kafatos, A, Koutis, A & Kogevinas, M 2009, 'The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus', Diabetes and Metabolism, vol. 35, no. 6, pp. 490-494. https://doi.org/10.1016/j.diabet.2009.07.003
Chatzi L, Plana E, Pappas A, Alegkakis D, Karakosta P, Daraki V et al. The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus. Diabetes and Metabolism. 2009 Dec 1;35(6):490-494. https://doi.org/10.1016/j.diabet.2009.07.003
Chatzi, L. ; Plana, E. ; Pappas, A. ; Alegkakis, D. ; Karakosta, P. ; Daraki, V. ; Vassilaki, Maria ; Tsatsanis, C. ; Kafatos, A. ; Koutis, A. ; Kogevinas, M. / The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus. In: Diabetes and Metabolism. 2009 ; Vol. 35, No. 6. pp. 490-494.
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