The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)

Jennifer L. Dearborn, David Knopman, A. Richey Sharrett, Andrea L.C. Schneider, Clifford R. Jack, Laura H. Coker, Alvaro Alonso, Elizabeth Selvin, Thomas H. Mosley, Lynne E. Wagenknecht, Beverly G. Windham, Rebecca F. Gottesman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).

Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).

Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.

Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.

Original languageEnglish (US)
Pages (from-to)337-346
Number of pages10
JournalDementia and geriatric cognitive disorders
Volume38
DOIs
StatePublished - Nov 7 2014

Keywords

  • Cognition
  • Cognitive decline
  • Dementia
  • Hypertension
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC)'. Together they form a unique fingerprint.

  • Cite this

    Dearborn, J. L., Knopman, D., Sharrett, A. R., Schneider, A. L. C., Jack, C. R., Coker, L. H., Alonso, A., Selvin, E., Mosley, T. H., Wagenknecht, L. E., Windham, B. G., & Gottesman, R. F. (2014). The metabolic syndrome and cognitive decline in the atherosclerosis risk in communities study (ARIC). Dementia and geriatric cognitive disorders, 38, 337-346. https://doi.org/10.1159/000362265