The mesenchymal stem cell secretome as an acellular regenerative therapy for liver disease

Julia Driscoll, Tushar C Patel

Research output: Contribution to journalReview article

Abstract

The use of mesenchymal stem cells (MSC) for tissue repair has garnered much interest and has been evaluated in several disease settings. Recent evidence indicates that the beneficial effects observed with MSC-based therapy can be mediated through the paracrine release of extracellular vesicles and other soluble proteins or biologically active molecules, which collectively constitute the MSC secretome. In this concise overview, we highlight results from preclinical and other studies that demonstrate the therapeutic efficacy of the MSC secretome for diseases that are characterized by liver injury or fibrosis. The potential for the use of the MSC secretome as an acellular regenerative therapy and approaches for the isolation of a secretome product for therapeutic applications are highlighted. The use of the MSC secretome as an acellular therapeutic agent could provide several advantages over the use of cell-based therapies for liver diseases.

Original languageEnglish (US)
JournalJournal of Gastroenterology
DOIs
StatePublished - Jan 1 2019

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Mesenchymal Stromal Cells
Liver Diseases
Cell- and Tissue-Based Therapy
Therapeutics
Fibrosis
Wounds and Injuries
Proteins

Keywords

  • Extracellular vesicles
  • Regenerative medicine
  • Secretome product
  • Stem cells

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The mesenchymal stem cell secretome as an acellular regenerative therapy for liver disease. / Driscoll, Julia; Patel, Tushar C.

In: Journal of Gastroenterology, 01.01.2019.

Research output: Contribution to journalReview article

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