The Meniscus Tear: A Review of Stem Cell Therapies

George Jacob, Kazunori Shimomura, Aaron J. Krych, Norimasa Nakamura

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Meniscal injuries have posed a challenging problem for many years, especially considering that historically the meniscus was considered to be a structure with no important role in the knee joint. This led to earlier treatments aiming at the removal of the entire structure in a procedure known as a meniscectomy. However, with the current understanding of the function and roles of the meniscus, meniscectomy has been identified to accelerate joint degradation significantly and is no longer a preferred treatment option in meniscal tears. Current therapies are now focused to regenerate, repair, or replace the injured meniscus to restore its native function. Repairs have improved in technique and materials over time, with various implant devices being utilized and developed. More recently, strategies have applied stem cells, tissue engineering, and their combination to potentiate healing to achieve superior quality repair tissue and retard the joint degeneration associated with an injured or inadequately functioning meniscus. Accordingly, the purpose of this current review is to summarize the current available pre-clinical and clinical literature using stem cells and tissue engineering for meniscal repair and regeneration.

Original languageEnglish (US)
JournalCells
Volume9
Issue number1
DOIs
StatePublished - Dec 30 2019

Keywords

  • meniscal regeneration
  • meniscal repair
  • meniscus
  • stem cell
  • tissue engineering

Fingerprint Dive into the research topics of 'The Meniscus Tear: A Review of Stem Cell Therapies'. Together they form a unique fingerprint.

  • Cite this