The Mechanobiology of Vascular Remodeling in the Aging Lung

Paul B. Dieffenbach; Aja Aravamudhan; Laura E. Fredenburgh; Daniel J. Tschumperlin

doi:10.1152/physiol.00019.2021

The Mechanobiology of Vascular Remodeling in the Aging Lung

Paul B. Dieffenbach, Aja Aravamudhan, Laura E. Fredenburgh, Daniel J. Tschumperlin

Physiology & Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

Abstract

Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how inter-acting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.

Original language	English (US)
Pages (from-to)	28-38
Number of pages	11
Journal	Physiology
Volume	37
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00019.2021
State	Published - Jan 2022

Keywords

Matrix
Pulmonary
Senescence
Stiffness
Vessel

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00019.2021

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abstract = "Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how inter-acting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.",

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author = "Dieffenbach, {Paul B.} and Aja Aravamudhan and Fredenburgh, {Laura E.} and Tschumperlin, {Daniel J.}",

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N2 - Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how inter-acting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.

AB - Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how inter-acting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.

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KW - Pulmonary

KW - Senescence

KW - Stiffness

KW - Vessel

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The Mechanobiology of Vascular Remodeling in the Aging Lung

Abstract

Keywords

ASJC Scopus subject areas

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