The mechanism of Axl-mediated ebola virus infection

Masayuki Shimojima, Yasuhiro Ikeda, Yoshihiro Kawaoka

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

We previously reported that expression of the receptor-type tyrosine kinase Axl, which regulates cell survival and activation, enhances both pseudotype and live Ebola virus (EBOV) infection. To clarify the mechanistic basis of this enhancement, we created a series of Axl mutants and identified amino acids/domains necessary for this function, by using a pseudotype virus carrying the EBOV glycoprotein (GP). Analyses of the Axl mutants showed the importance of extracellular and intracellular regions for Axl functions, including ligand binding and signal transduction, in EBOV GP-mediated infection. These data suggest that EBOV uses the physiological functions of Axl to enter cells.

Original languageEnglish (US)
Pages (from-to)S259-S263
JournalJournal of Infectious Diseases
Volume196
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 15 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Shimojima, M., Ikeda, Y., & Kawaoka, Y. (2007). The mechanism of Axl-mediated ebola virus infection. Journal of Infectious Diseases, 196(SUPPL. 2), S259-S263. https://doi.org/10.1086/520594