The mechanism of Axl-mediated ebola virus infection

Masayuki Shimojima, Yasuhiro H Ikeda, Yoshihiro Kawaoka

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

We previously reported that expression of the receptor-type tyrosine kinase Axl, which regulates cell survival and activation, enhances both pseudotype and live Ebola virus (EBOV) infection. To clarify the mechanistic basis of this enhancement, we created a series of Axl mutants and identified amino acids/domains necessary for this function, by using a pseudotype virus carrying the EBOV glycoprotein (GP). Analyses of the Axl mutants showed the importance of extracellular and intracellular regions for Axl functions, including ligand binding and signal transduction, in EBOV GP-mediated infection. These data suggest that EBOV uses the physiological functions of Axl to enter cells.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume196
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 15 2007

Fingerprint

Ebola Hemorrhagic Fever
Ebolavirus
Glycoproteins
Signal Transduction
Cell Survival
Ligands
Viruses
Amino Acids
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The mechanism of Axl-mediated ebola virus infection. / Shimojima, Masayuki; Ikeda, Yasuhiro H; Kawaoka, Yoshihiro.

In: Journal of Infectious Diseases, Vol. 196, No. SUPPL. 2, 15.11.2007.

Research output: Contribution to journalArticle

Shimojima, Masayuki ; Ikeda, Yasuhiro H ; Kawaoka, Yoshihiro. / The mechanism of Axl-mediated ebola virus infection. In: Journal of Infectious Diseases. 2007 ; Vol. 196, No. SUPPL. 2.
@article{dc83d58353ce4e07a1b04b6d0992e0e3,
title = "The mechanism of Axl-mediated ebola virus infection",
abstract = "We previously reported that expression of the receptor-type tyrosine kinase Axl, which regulates cell survival and activation, enhances both pseudotype and live Ebola virus (EBOV) infection. To clarify the mechanistic basis of this enhancement, we created a series of Axl mutants and identified amino acids/domains necessary for this function, by using a pseudotype virus carrying the EBOV glycoprotein (GP). Analyses of the Axl mutants showed the importance of extracellular and intracellular regions for Axl functions, including ligand binding and signal transduction, in EBOV GP-mediated infection. These data suggest that EBOV uses the physiological functions of Axl to enter cells.",
author = "Masayuki Shimojima and Ikeda, {Yasuhiro H} and Yoshihiro Kawaoka",
year = "2007",
month = "11",
day = "15",
doi = "10.1086/520594",
language = "English (US)",
volume = "196",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "SUPPL. 2",

}

TY - JOUR

T1 - The mechanism of Axl-mediated ebola virus infection

AU - Shimojima, Masayuki

AU - Ikeda, Yasuhiro H

AU - Kawaoka, Yoshihiro

PY - 2007/11/15

Y1 - 2007/11/15

N2 - We previously reported that expression of the receptor-type tyrosine kinase Axl, which regulates cell survival and activation, enhances both pseudotype and live Ebola virus (EBOV) infection. To clarify the mechanistic basis of this enhancement, we created a series of Axl mutants and identified amino acids/domains necessary for this function, by using a pseudotype virus carrying the EBOV glycoprotein (GP). Analyses of the Axl mutants showed the importance of extracellular and intracellular regions for Axl functions, including ligand binding and signal transduction, in EBOV GP-mediated infection. These data suggest that EBOV uses the physiological functions of Axl to enter cells.

AB - We previously reported that expression of the receptor-type tyrosine kinase Axl, which regulates cell survival and activation, enhances both pseudotype and live Ebola virus (EBOV) infection. To clarify the mechanistic basis of this enhancement, we created a series of Axl mutants and identified amino acids/domains necessary for this function, by using a pseudotype virus carrying the EBOV glycoprotein (GP). Analyses of the Axl mutants showed the importance of extracellular and intracellular regions for Axl functions, including ligand binding and signal transduction, in EBOV GP-mediated infection. These data suggest that EBOV uses the physiological functions of Axl to enter cells.

UR - http://www.scopus.com/inward/record.url?scp=38449119465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449119465&partnerID=8YFLogxK

U2 - 10.1086/520594

DO - 10.1086/520594

M3 - Article

C2 - 17940958

AN - SCOPUS:38449119465

VL - 196

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - SUPPL. 2

ER -