TY - JOUR
T1 - The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms
T2 - Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease
AU - Mayo Clinic Histiocytosis Working Group
AU - Goyal, Gaurav
AU - Young, Jason R.
AU - Koster, Matthew J.
AU - Tobin, W. Oliver
AU - Vassallo, Robert
AU - Ryu, Jay H.
AU - Davidge-Pitts, Caroline J.
AU - Hurtado, Maria D.
AU - Ravindran, Aishwarya
AU - Sartori Valinotti, Julio C.
AU - Bennani, N. Nora
AU - Shah, Mithun V.
AU - Rech, Karen L.
AU - Go, Ronald S.
N1 - Publisher Copyright:
© 2019 Mayo Foundation for Medical Education and Research
PY - 2019/10
Y1 - 2019/10
N2 - Histiocytic neoplasms, a rare and heterogeneous group of disorders, primarily include Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. Due to their diverse clinical manifestations, the greatest challenge posed by these neoplasms is the establishment of a diagnosis, which often leads to a delay in institution of appropriate therapy. Recent insights into their genomic architecture demonstrating mitogen-activated protein kinase/extracellular signal–regulated kinase pathway mutations have now enabled potential treatment with targeted therapies in most patients. This consensus statement represents a joint document from a multidisciplinary group of physicians at Mayo Clinic who specialize in the management of adult histiocytic neoplasms. It consists of evidence- and consensus-based recommendations on when to suspect these neoplasms and what tests to order for the diagnosis and initial evaluation. In addition, it also describes the histopathologic and individual organ manifestations of these neoplasms to help the clinicians in identifying their key features. With uniform guidelines that aid in identifying these neoplasms, we hope to improve the awareness that may lead to their timely and correct diagnosis.
AB - Histiocytic neoplasms, a rare and heterogeneous group of disorders, primarily include Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. Due to their diverse clinical manifestations, the greatest challenge posed by these neoplasms is the establishment of a diagnosis, which often leads to a delay in institution of appropriate therapy. Recent insights into their genomic architecture demonstrating mitogen-activated protein kinase/extracellular signal–regulated kinase pathway mutations have now enabled potential treatment with targeted therapies in most patients. This consensus statement represents a joint document from a multidisciplinary group of physicians at Mayo Clinic who specialize in the management of adult histiocytic neoplasms. It consists of evidence- and consensus-based recommendations on when to suspect these neoplasms and what tests to order for the diagnosis and initial evaluation. In addition, it also describes the histopathologic and individual organ manifestations of these neoplasms to help the clinicians in identifying their key features. With uniform guidelines that aid in identifying these neoplasms, we hope to improve the awareness that may lead to their timely and correct diagnosis.
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U2 - 10.1016/j.mayocp.2019.02.023
DO - 10.1016/j.mayocp.2019.02.023
M3 - Review article
C2 - 31472931
AN - SCOPUS:85071315667
SN - 0025-6196
VL - 94
SP - 2054
EP - 2071
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 10
ER -