The mayo clinic Arizona spasmodic dysphonia experience: A demographic analysis of 718 patients

Alpen B. Patel, Stephen F. Bansberg, Charles Howard Adler, David G Lott, Lisa Crujido

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Analyze demographic data collected over a 25-year experience of 718 patients with spasmodic dysphonia (SD) who have been treated with botulinum toxin-A (BoNT-A) and compare our data with previously published studies. Methods: Seven hundred eighteen patients with SD were treated with 6621 BoNT-A injections at Mayo Clinic Arizona between 1989 and 2014. All patients were treated by the same physician team. Background demographic data for each patient were recorded. Results: Of 718 patients, 557 patients were female (77.6%). Six hundred sixty of 718 (91.8%) patients had adductor SD (AdSD), and 58 of 718 (8.1%) patients had abductor SD (AbSD). Average age of onset was 51 years. Of 718 patients, 378 (52.6%) had vocal tremor (VT); VT was present in 54.4% of AdSD patients and 32.1% of AbSD patients. Thirty-seven of 718 (5.2%) patients had other dystonias, including cervical dystonia (2.3%), blepharospasm (1.4%), limb dystonia (1.1%), and oromandibular dystonia (0.3%). A positive family history of SD was present in only 6 of 718 patients (0.8%) and of other dystonias in 11 of 718 patients (1.5%). Conclusions: Spasmodic dysphonia is a chronic and potentially disabling focal laryngeal dystonia. The Mayo Clinic Arizona SD experience compares to prior reports and reveals a female preponderance, onset in middle age, infrequent hereditary pattern, high co-occurrence of VT, and low co-occurrence of other dystonias.

Original languageEnglish (US)
Pages (from-to)859-863
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume124
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Dysphonia
Demography
Dystonia
Tremor
Type A Botulinum Toxins
Blepharospasm
Dystonic Disorders
Torticollis
Age of Onset

Keywords

  • botulinum toxin
  • dysphonia
  • dystonia
  • spasmodic dysphonia
  • voice

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

The mayo clinic Arizona spasmodic dysphonia experience : A demographic analysis of 718 patients. / Patel, Alpen B.; Bansberg, Stephen F.; Adler, Charles Howard; Lott, David G; Crujido, Lisa.

In: Annals of Otology, Rhinology and Laryngology, Vol. 124, No. 11, 01.11.2015, p. 859-863.

Research output: Contribution to journalArticle

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abstract = "Objective: Analyze demographic data collected over a 25-year experience of 718 patients with spasmodic dysphonia (SD) who have been treated with botulinum toxin-A (BoNT-A) and compare our data with previously published studies. Methods: Seven hundred eighteen patients with SD were treated with 6621 BoNT-A injections at Mayo Clinic Arizona between 1989 and 2014. All patients were treated by the same physician team. Background demographic data for each patient were recorded. Results: Of 718 patients, 557 patients were female (77.6{\%}). Six hundred sixty of 718 (91.8{\%}) patients had adductor SD (AdSD), and 58 of 718 (8.1{\%}) patients had abductor SD (AbSD). Average age of onset was 51 years. Of 718 patients, 378 (52.6{\%}) had vocal tremor (VT); VT was present in 54.4{\%} of AdSD patients and 32.1{\%} of AbSD patients. Thirty-seven of 718 (5.2{\%}) patients had other dystonias, including cervical dystonia (2.3{\%}), blepharospasm (1.4{\%}), limb dystonia (1.1{\%}), and oromandibular dystonia (0.3{\%}). A positive family history of SD was present in only 6 of 718 patients (0.8{\%}) and of other dystonias in 11 of 718 patients (1.5{\%}). Conclusions: Spasmodic dysphonia is a chronic and potentially disabling focal laryngeal dystonia. The Mayo Clinic Arizona SD experience compares to prior reports and reveals a female preponderance, onset in middle age, infrequent hereditary pattern, high co-occurrence of VT, and low co-occurrence of other dystonias.",
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