TY - JOUR
T1 - The management of myocarditis
AU - Schultheiss, Heinz Peter
AU - Khl, Uwe
AU - Cooper, Leslie T.
N1 - Funding Information:
Basic experimental diagnostic and clinical works have been supported by a grant from the German Research Foundation (DFG), Transregio-nal Collaborative Research Centre ‘Inflammatory Cardiomyopathy– Molecular Pathogenesis and Therapy’ (SFB TR 19 04) (HPS, UK, Charite Berlin).
PY - 2011/11
Y1 - 2011/11
N2 - Despite considerable advances in our understanding of myocarditis pathogenesis, the clinical management of myocarditis has changed relatively little in the last few years. This review aims to help bridge the widening gap between recent mechanistic insights, which are largely derived from animal models, and their potential impact on disease burden. We illustrate the pathogenenic mechanisms that are prime targets for novel therapeutic interventions. Pathway and pathogen-specific molecular diagnostic tests have expanded the role for endomyocardial biopsy. State of the art cardiac magnetic resonance imaging can now provide non-invasive tissue characterization and localize inflammatory infiltrates but imaging techniques are misleading if infectious agents are involved. We emphasize the gaps in our current clinical knowledge, particularly with respect to aetiology-based therapy, and suggest opportunities for high impact, translational investigations.
AB - Despite considerable advances in our understanding of myocarditis pathogenesis, the clinical management of myocarditis has changed relatively little in the last few years. This review aims to help bridge the widening gap between recent mechanistic insights, which are largely derived from animal models, and their potential impact on disease burden. We illustrate the pathogenenic mechanisms that are prime targets for novel therapeutic interventions. Pathway and pathogen-specific molecular diagnostic tests have expanded the role for endomyocardial biopsy. State of the art cardiac magnetic resonance imaging can now provide non-invasive tissue characterization and localize inflammatory infiltrates but imaging techniques are misleading if infectious agents are involved. We emphasize the gaps in our current clinical knowledge, particularly with respect to aetiology-based therapy, and suggest opportunities for high impact, translational investigations.
KW - Clinical management
KW - Myocarditis pathogenesis
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U2 - 10.1093/eurheartj/ehr165
DO - 10.1093/eurheartj/ehr165
M3 - Review article
C2 - 21705357
AN - SCOPUS:80755129458
SN - 0195-668X
VL - 32
SP - 2616
EP - 2625
JO - European heart journal
JF - European heart journal
IS - 21
ER -