The management of myocarditis

Heinz Peter Schultheiss, Uwe Khl, Leslie T Jr. Cooper

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Despite considerable advances in our understanding of myocarditis pathogenesis, the clinical management of myocarditis has changed relatively little in the last few years. This review aims to help bridge the widening gap between recent mechanistic insights, which are largely derived from animal models, and their potential impact on disease burden. We illustrate the pathogenenic mechanisms that are prime targets for novel therapeutic interventions. Pathway and pathogen-specific molecular diagnostic tests have expanded the role for endomyocardial biopsy. State of the art cardiac magnetic resonance imaging can now provide non-invasive tissue characterization and localize inflammatory infiltrates but imaging techniques are misleading if infectious agents are involved. We emphasize the gaps in our current clinical knowledge, particularly with respect to aetiology-based therapy, and suggest opportunities for high impact, translational investigations.

Original languageEnglish (US)
Pages (from-to)2616-2625
Number of pages10
JournalEuropean Heart Journal
Volume32
Issue number21
DOIs
StatePublished - Nov 2011

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Myocarditis
Molecular Pathology
Routine Diagnostic Tests
Animal Models
Magnetic Resonance Imaging
Biopsy
Therapeutics

Keywords

  • Clinical management
  • Myocarditis pathogenesis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The management of myocarditis. / Schultheiss, Heinz Peter; Khl, Uwe; Cooper, Leslie T Jr.

In: European Heart Journal, Vol. 32, No. 21, 11.2011, p. 2616-2625.

Research output: Contribution to journalArticle

Schultheiss, Heinz Peter ; Khl, Uwe ; Cooper, Leslie T Jr. / The management of myocarditis. In: European Heart Journal. 2011 ; Vol. 32, No. 21. pp. 2616-2625.
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