The management and outcome of spinal implant infections: Contemporary retrospective cohort study

Todd J. Kowalski, Elie F. Berbari, Paul M. Huddleston, James M. Steckelberg, Jayawant Mandrekar, Douglas R. Osmon

Research output: Contribution to journalArticle

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Abstract

Background. Spinal implant infections provide unique diagnostic and therapeutic challenges. Methods. We conducted a retrospective cohort study to evaluate risk factors for treatment failure in patients with early- and late- onset spinal implant infections at the Mayo Clinic (Rochester, MN) during 1994-2002. Results. We identified 30 patients with early-onset spinal implant infection and 51 patients with late-onset spinal implant infection. Twenty-eight of 30 patients with early-onset infection were treated with debridement, implant retention, and antimicrobial therapy. The estimated 2-year cumulative probability of survival free of treatment failure for patients with early-onset infection was 71% (95% confidence interval [CI], 51%-85%). Thirty-two of 51 patients with late-onset infection were treated with implant removal. Their estimated 2-year cumulative probability of survival free of treatment failure was 84% (95% CI, 66%-93%). For patients with early-onset infections, receiving oral antimicrobial suppression therapy was associated with increased cumulative probability of survival (hazard ratio, 0.2; 95% CI, 0.1-0.7). For patients with late-onset infections, implant removal was associated with increased cumulative probability of survival (hazard ratio, 0.3; 95% CI, 0.1-0.7). Conclusions. Early-onset spinal implant infections are successfully treated with debridement, implant retention, and parenteral followed by oral suppressive antimicrobial therapy. Implant removal is associated with successful outcomes in late-onset infections.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalClinical Infectious Diseases
Volume44
Issue number7
DOIs
StatePublished - Apr 1 2007

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Cohort Studies
Retrospective Studies
Infection
Treatment Failure
Confidence Intervals
Survival
Debridement
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Kowalski, T. J., Berbari, E. F., Huddleston, P. M., Steckelberg, J. M., Mandrekar, J., & Osmon, D. R. (2007). The management and outcome of spinal implant infections: Contemporary retrospective cohort study. Clinical Infectious Diseases, 44(7), 913-920. https://doi.org/10.1086/512194

The management and outcome of spinal implant infections : Contemporary retrospective cohort study. / Kowalski, Todd J.; Berbari, Elie F.; Huddleston, Paul M.; Steckelberg, James M.; Mandrekar, Jayawant; Osmon, Douglas R.

In: Clinical Infectious Diseases, Vol. 44, No. 7, 01.04.2007, p. 913-920.

Research output: Contribution to journalArticle

Kowalski, TJ, Berbari, EF, Huddleston, PM, Steckelberg, JM, Mandrekar, J & Osmon, DR 2007, 'The management and outcome of spinal implant infections: Contemporary retrospective cohort study', Clinical Infectious Diseases, vol. 44, no. 7, pp. 913-920. https://doi.org/10.1086/512194
Kowalski, Todd J. ; Berbari, Elie F. ; Huddleston, Paul M. ; Steckelberg, James M. ; Mandrekar, Jayawant ; Osmon, Douglas R. / The management and outcome of spinal implant infections : Contemporary retrospective cohort study. In: Clinical Infectious Diseases. 2007 ; Vol. 44, No. 7. pp. 913-920.
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