The Liver and Glycogen: In Sickness and in Health

Gwyneth S.T. Soon, Michael Torbenson

Research output: Contribution to journalReview articlepeer-review


The liver is a major store of glycogen and is essential in maintaining systemic glucose homeostasis. In healthy individuals, glycogen synthesis and breakdown in the liver are tightly regulated. Abnormal glycogen metabolism results in prominent pathological changes in the liver, often manifesting as hepatic glycogenosis or glycogen inclusions. This can occur in genetic glycogen storage disease or acquired conditions with insulin dysregulation such as diabetes mellitus and non-alcoholic fatty liver disease or medication effects. Some primary hepatic tumors such as clear cell hepatocellular carcinoma also demonstrate excessive glycogen accumulation. This review provides an overview of the pathological manifestations and molecular mechanisms of liver diseases associated with abnormal glycogen accumulation.

Original languageEnglish (US)
Article number6133
JournalInternational journal of molecular sciences
Issue number7
StatePublished - Apr 2023


  • Mauriac syndrome
  • clear cell hepatocellular carcinoma
  • glycogenic hepatopathy
  • hepatic glycogenosis
  • pathology
  • pseudoground glass

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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