Abstract
Background: Vps4 functions in eukaryotic cells in membrane fission reactions. Results: Mutational analysis suggests that the long linker region of Vps4 is not essential but regulates this ATPase. Conclusion: The binding to the substrate ESCRT-III drives formation of the active Vps4 complex. Significance: Understanding the mechanism of Vps4 function gives insights into protein trafficking, cytokinesis, and virus formation.
Original language | English (US) |
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Pages (from-to) | 26810-26819 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 37 |
DOIs | |
State | Published - Sep 13 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology