The Linker Region Plays a Regulatory Role in Assembly and Activity of the Vps4 AAA ATPase

Anna Shestakova, Matt Curtiss, Brian A. Davies, David J. Katzmann, Markus Babst

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Vps4 functions in eukaryotic cells in membrane fission reactions. Results: Mutational analysis suggests that the long linker region of Vps4 is not essential but regulates this ATPase. Conclusion: The binding to the substrate ESCRT-III drives formation of the active Vps4 complex. Significance: Understanding the mechanism of Vps4 function gives insights into protein trafficking, cytokinesis, and virus formation.

Original languageEnglish (US)
Pages (from-to)26810-26819
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
StatePublished - Sep 13 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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