Abstract
Introduction: We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid β (Aβ) to duration of illness in dementia with Lewy bodies (DLB). Methods: Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aβ was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration. Results: Patients with diffuse Lewy body disease had more severe pathology of each type and a shorter duration of illness than individuals with transitional Lewy body disease. The three pathologies accounted for 25% of the total variance of duration of illness, with 19% accounted for by α-synuclein alone or in combination with tau and Aβ. When the diffuse Lewy body disease group was examined separately, α-synuclein deposition significantly exceeded that of tau and Aβ. In this model, 20% of 24% total variance in the model for duration of illness was accounted for independently by α-synuclein. Discussion: In DLB, α-synuclein is an important predictor of disease duration, both independently and synergistically with tau and Aβ.
Original language | English (US) |
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Pages (from-to) | 330-339 |
Number of pages | 10 |
Journal | Alzheimer's and Dementia |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2018 |
Keywords
- Alzheimer's disease
- Commonality analysis
- Lewy body
- Parkinsonism
- Pathology
- REM sleep behavior disorder
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Clinical Neurology
- Geriatrics and Gerontology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health