The life cycle of a T cell after vaccination – where does immune ageing strike?

C. Kim, F. Fang, C. M. Weyand, J. J. Goronzy

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Vaccination is the optimal intervention to prevent the increased morbidity and mortality from infection in older individuals and to maintain immune health during ageing. To optimize benefits from vaccination, strategies have to be developed that overcome the defects in an adaptive immune response that occur with immune ageing. Most current approaches are concentrated on activating the innate immune system by adjuvants to improve the induction of a T cell response. This review will focus upon T cell-intrinsic mechanisms that control how a T cell is activated, expands rapidly to differentiate into short-lived effector cells and into memory precursor cells, with short-lived effector T cells then mainly undergoing apoptosis and memory precursor cells surviving as long-lived memory T cells. Insights into each step of this longitudinal course of a T cell response that takes place over a period of several weeks is beginning to allow identifying interventions that can improve this process of T cell memory generation and specifically target defects that occur with ageing.

Original languageEnglish (US)
Pages (from-to)71-81
Number of pages11
JournalClinical and Experimental Immunology
Volume187
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • aging
  • immunosenescence
  • T cell memory
  • T cell receptor repertoire
  • T cell response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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