The left ventricle responds to acute graded elevation of right ventricular afterload by augmentation of twist magnitude and untwist rate

Eun Joo Cho, Panupong Jiamsripong, Anna M. Calleja, Mohsen S. Alharthi, Eileen M. McMahon, Krishnaswamy Chandrasekaran, Stephen Cha, Anna E. Bukatina, Bijoy K. Khandheria, Marek Belohlavek

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Abstract

Background: The right and left ventricles share the interventricular septum, which mechanically transmits pressure gradients. The aim of this study was to investigate how acute mild or moderate right ventricular (RV) afterload affects left ventricular (LV) function. Methods: In 14 open-chest pigs (mean weight, 43 ± 4 kg) with preserved pericardium, acute mild (>35 and ≤50 mm Hg) and moderate (>50 and ≤60 mm Hg) RV pressure loading conditions were induced by constriction of the pulmonary artery. Hemodynamic parameters and LV twist and untwist were evaluated under each condition. Results: From baseline to mild and moderate RV afterload, the mean RV systolic pressure increased from 31.0 ± 4.3 to 41.1 ± 2.7 and 52.7 ± 3.4 mm Hg (P <.001), while LV twist magnitudes increased from 15.4 ± 5.1° to 18.5 ± 3.1° and 19.8 ± 5.0° (P =.004), respectively. Absolute values of LV untwist rate increased from -116.9 ± 64.9°/sec to -160.0 ± 53.3°/sec and -169.1 ± 47.0°/sec, respectively (P =.001). After adjusting for all variables, only the ratio of the early and atrial components of mitral inflow and RV outflow tract acceleration time was significantly associated with the LV twist magnitude and LV untwist rate. Conclusions: In an acute setting, the left ventricle responds to suddenly elevated RV afterload and decreased RV stroke volume by promptly increasing its twist magnitude and untwist rate.

Original languageEnglish (US)
Pages (from-to)922-929
Number of pages8
JournalJournal of the American Society of Echocardiography
Volume24
Issue number8
DOIs
StatePublished - Aug 2011

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Keywords

  • Blood pressure
  • Contractility
  • Ventricles

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Cho, E. J., Jiamsripong, P., Calleja, A. M., Alharthi, M. S., McMahon, E. M., Chandrasekaran, K., Cha, S., Bukatina, A. E., Khandheria, B. K., & Belohlavek, M. (2011). The left ventricle responds to acute graded elevation of right ventricular afterload by augmentation of twist magnitude and untwist rate. Journal of the American Society of Echocardiography, 24(8), 922-929. https://doi.org/10.1016/j.echo.2011.04.011