The janus head of T cell aging-autoimmunity and immunodeficiency

Jörg J. Goronzy, Guangjin Li, Zhen Yang, Cornelia M. Weyand

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in the elderly. Why an immune system that suboptimally responds to exogenous antigen fails to maintain tolerance to self-antigens appears to be perplexing. In this review, we will discuss age-associated deviations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum.

Original languageEnglish (US)
Article numberArticle 131
JournalFrontiers in immunology
Volume4
Issue numberJUN
DOIs
StatePublished - 2013

Keywords

  • Autoimmunity
  • Dna damage response
  • Giant cell arteritis
  • Immunosenescence
  • Inflammation
  • Pathogenesis
  • Rheumatoid arthritis
  • T cell receptor signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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