The JAK2 V617F mutation is absent in patients with erythrocytosis due to high oxygen affinity hemoglobin variants

Rebecca F. McClure, James D. Hoyer, Ming Mai

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

High oxygen affinity hemoglobin (Hb) variants are an important and well characterized cause of secondary erythrocytosis. We tested 22 patients with high oxygen affinity β chain variants for the presence of the JAK2 V617F mutation that has been reported in chronic myeloproliferative disorders, particularly polycythemia vera. All specimens showed the absence of this mutation. This observation contributes to the overall clinical specificity of the JAK2 V617F mutation.

Original languageEnglish (US)
Pages (from-to)487-489
Number of pages3
JournalHemoglobin
Volume30
Issue number4
DOIs
StatePublished - Dec 1 2006

Keywords

  • High oxygen affinity hemoglobin (Hb) variants
  • JAK2 V617F mutation
  • Secondary erythrocytosis

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'The JAK2 V617F mutation is absent in patients with erythrocytosis due to high oxygen affinity hemoglobin variants'. Together they form a unique fingerprint.

  • Cite this