The JAK2 V617F mutation is absent in patients with erythrocytosis due to high oxygen affinity hemoglobin variants

Rebecca F. McClure; James D. Hoyer; Ming Mai

doi:10.1080/03630260600868147

The JAK2 V617F mutation is absent in patients with erythrocytosis due to high oxygen affinity hemoglobin variants

Rebecca F. McClure, James D. Hoyer, Ming Mai

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

High oxygen affinity hemoglobin (Hb) variants are an important and well characterized cause of secondary erythrocytosis. We tested 22 patients with high oxygen affinity β chain variants for the presence of the JAK2 V617F mutation that has been reported in chronic myeloproliferative disorders, particularly polycythemia vera. All specimens showed the absence of this mutation. This observation contributes to the overall clinical specificity of the JAK2 V617F mutation.

Original language	English (US)
Pages (from-to)	487-489
Number of pages	3
Journal	Hemoglobin
Volume	30
Issue number	4
DOIs	https://doi.org/10.1080/03630260600868147
State	Published - Dec 1 2006

Keywords

High oxygen affinity hemoglobin (Hb) variants
JAK2 V617F mutation
Secondary erythrocytosis

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Genetics(clinical)
Biochemistry, medical

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10.1080/03630260600868147

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abstract = "High oxygen affinity hemoglobin (Hb) variants are an important and well characterized cause of secondary erythrocytosis. We tested 22 patients with high oxygen affinity β chain variants for the presence of the JAK2 V617F mutation that has been reported in chronic myeloproliferative disorders, particularly polycythemia vera. All specimens showed the absence of this mutation. This observation contributes to the overall clinical specificity of the JAK2 V617F mutation.",

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AU - Hoyer, James D.

AU - Mai, Ming

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N2 - High oxygen affinity hemoglobin (Hb) variants are an important and well characterized cause of secondary erythrocytosis. We tested 22 patients with high oxygen affinity β chain variants for the presence of the JAK2 V617F mutation that has been reported in chronic myeloproliferative disorders, particularly polycythemia vera. All specimens showed the absence of this mutation. This observation contributes to the overall clinical specificity of the JAK2 V617F mutation.

AB - High oxygen affinity hemoglobin (Hb) variants are an important and well characterized cause of secondary erythrocytosis. We tested 22 patients with high oxygen affinity β chain variants for the presence of the JAK2 V617F mutation that has been reported in chronic myeloproliferative disorders, particularly polycythemia vera. All specimens showed the absence of this mutation. This observation contributes to the overall clinical specificity of the JAK2 V617F mutation.

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KW - Secondary erythrocytosis

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The JAK2 V617F mutation is absent in patients with erythrocytosis due to high oxygen affinity hemoglobin variants

Abstract

Keywords

ASJC Scopus subject areas

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