The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo

Eunhee S. Yi, Daniel G. Remick, Young Lim, Winson Tang, Christine E. Nadzienko, Adriana Bedoya, Songmei Yin, Thomas R. Ulich

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Intratracheal instillation of endotoxin (LPS) causes acute pulmonary inflammation characterized by the accumulation of plasma proteins and leukocytes within the pulmonary airways. The synthetic glucocorticoid dexamethasone 1) inhibits the LPS-initiated vascular leak of plasma proteins into the airspace, 2) inhibits the LPS-initiated emigration of neutrophils and lymphocytes into the airspace in a dose-dependent fashion, and 3) inhibits LPS-initiated mRNA and/or bronchoalveolar lavage protein expression of cytokines (TNF, IL-1 and IL-6) and chemokines (MIP-1α, MIP-2 and MCP-1). In conclusion, dexamethasone inhibits both the vascular and cellular aspects of acute inflammation by downregulation of a broad spectrum of inflammatory cytokines and chemokines.

Original languageEnglish (US)
Pages (from-to)165-175
Number of pages11
JournalInflammation
Volume20
Issue number2
DOIs
StatePublished - May 10 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo'. Together they form a unique fingerprint.

  • Cite this

    Yi, E. S., Remick, D. G., Lim, Y., Tang, W., Nadzienko, C. E., Bedoya, A., Yin, S., & Ulich, T. R. (1996). The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo. Inflammation, 20(2), 165-175. https://doi.org/10.1007/BF01487403