La interpretación de los ensayos clínicos negativos

Translated title of the contribution: The interpretation of negative randomized clinical trials

Francisco López-Jiménez, David Paniagua, Gervasio A. Lamas

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Randomized clinical trials without statistically significant differences between treatment groups may provide useful information for clinicians. However, negative trials must be interpreted cautiously, since the absence of evidence of treatment effect is not the same as evidence of absence of treatment effect. Before the reader of a negative article can conclude that one intervention was not better than the other, the potential causes of a negative study should be explored. The objective of this manuscript is to critically describe some of the most common methodological problems that can explain the lack of difference between studied groups in randomized clinical trials.

Translated title of the contributionThe interpretation of negative randomized clinical trials
Original languageSpanish
Pages (from-to)435-440
Number of pages6
JournalRevista de Investigacion Clinica
Volume50
Issue number5
StatePublished - Sep 1 1998

Keywords

  • Evidence-based medicine
  • Randomized clinical trial
  • Sample size
  • Statistical power

ASJC Scopus subject areas

  • Medicine(all)

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