TY - JOUR
T1 - The international consensus classification of myeloid neoplasms and acute Leukemias
T2 - myeloproliferative neoplasms
AU - Thiele, Jürgen
AU - Kvasnicka, Hans Michael
AU - Orazi, Attilio
AU - Gianelli, Umberto
AU - Gangat, Naseema
AU - Vannucchi, Alessandro M.
AU - Barbui, Tiziano
AU - Arber, Daniel A.
AU - Tefferi, Ayalew
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2023/1
Y1 - 2023/1
N2 - A group of international experts, including hematopathologists, oncologists, and geneticists were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World Health Organization classification system for hematopoietic tumors. After careful deliberation, the group introduced the new International Consensus Classification (ICC) for Myeloid Neoplasms and Acute Leukemias. This current in-depth review focuses on the ICC-2022 category of JAK2 mutation-prevalent myeloproliferative neoplasms (MPNs): essential thrombocythemia, polycythemia vera, primary myelofibrosis, and MPN, unclassifiable. The ICC MPN subcommittee chose to preserve the primary role of bone marrow morphology in disease classification and diagnostics, while also acknowledging the complementary role of genetic markers for establishing clonality, facilitating MPN subtype designation, and disease prognostication.
AB - A group of international experts, including hematopathologists, oncologists, and geneticists were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World Health Organization classification system for hematopoietic tumors. After careful deliberation, the group introduced the new International Consensus Classification (ICC) for Myeloid Neoplasms and Acute Leukemias. This current in-depth review focuses on the ICC-2022 category of JAK2 mutation-prevalent myeloproliferative neoplasms (MPNs): essential thrombocythemia, polycythemia vera, primary myelofibrosis, and MPN, unclassifiable. The ICC MPN subcommittee chose to preserve the primary role of bone marrow morphology in disease classification and diagnostics, while also acknowledging the complementary role of genetic markers for establishing clonality, facilitating MPN subtype designation, and disease prognostication.
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U2 - 10.1002/ajh.26751
DO - 10.1002/ajh.26751
M3 - Review article
C2 - 36200127
AN - SCOPUS:85141413774
SN - 0361-8609
VL - 98
SP - 166
EP - 179
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 1
ER -