@article{042d307fc7f34ee8ad58a7718fe19990,
title = "The interface of pancreatic cancer with diabetes, obesity, and inflammation: Research gaps and opportunities: Summary of a national Institute of Diabetes and digestive and kidney diseases workshop",
abstract = "A workshop on “The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities” was held by the National Institute of Diabetes and Digestive and Kidney Diseases on October 12, 2017. The purpose of the workshop was to explore the relationship and possible mechanisms of the increased risk of pancreatic ductal adenocarcinoma (PDAC) related to diabetes, the role of altered intracellular energy metabolism in PDAC, the mechanisms and biomarkers of diabetes caused by PDAC, the mechanisms of the increased risk of PDAC associated with obesity, and the role of inflammatory events and mediators as contributing causes of the development of PDAC. Workshop faculty reviewed the state of the current knowledge in these areas and made recommendations for future research efforts. Further knowledge is needed to elucidate the basic mechanisms contributing to the role of hyperinsulinemia, hyperglycemia, adipokines, and acute and chronic inflammatory events on the development of PDAC.",
keywords = "Diabetes, Inflammation, Obesity, Pancreatic cancer, Research gaps",
author = "Abbruzzese, {James L.} and Andersen, {Dana K.} and Borrebaeck, {Carl A.K.} and Chari, {Suresh T.} and Eithne Costello and Zobeida Cruz-Monserrate and Guido Eibl and Engleman, {Edgar G.} and Fisher, {William E.} and Aida Habtezion and Kim, {Seung K.} and Murray Korc and Craig Logsdon and Lyssiotis, {Costas A.} and Pandol, {Stephen J.} and Anil Rustgi and Wolfe, {Bruce M.} and Lei Zheng and Powers, {Alvin C.}",
note = "Funding Information: The authors acknowledge with thanks the support provided by the Pancreatic Cancer Action Network for this workshop. Funding Information: Oncology and Surgery, Johns Hopkins University, Baltimore, MD; and ¶¶¶Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center; and ###Department of Molecular Physiology & Biophysics, Vanderbilt University, VA Tennessee Valley Healthcare, Nashville, TN. Received for publication February 3, 2018; accepted February 20, 2018. Address correspondence to: James L. Abbruzzese, MD, Duke University Medical Center, 10 Bryan Searle Dr, Seeley G. Mudd Bldg, Room 440, Duke University Medical Center, Durham, NC 27710 (e‐mail: james.abbruzzese@duke.edu). Supported in part by Public Health Services and other grants: P50 CA014236 (to J.L.A.), P01 CA163200 (to G.E.), R01 CA075059 and U01 DK 108323 (to M.K.), R01 DK060694 (to A.R.), Pancreatic Cancer UK, Pancreatic Cancer Action Network and the NIHR Clinical Research Network grants (to E.C), and a Pancreatic Cancer Action Network/AACR Pathway to Leadership award 13-70-25-LYSS (to C.A.L.). Logistical support was provided by the Scientific Consulting Group, Inc, and by Mr Mark Dennis. This workshop was endorsed by the Consortium for the Study of Pancreatitis, Diabetes, and Pancreatic Cancer supported by the National Cancer Institute and the National Institute of Diabetes and Digestive and Kidney Diseases. The authors declare no conflict of interest. Copyright {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001037 Publisher Copyright: Copyright {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2018",
month = may,
day = "1",
doi = "10.1097/MPA.0000000000001037",
language = "English (US)",
volume = "47",
pages = "516--525",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "5",
}