DIE INTERAKTION ZWISCHEN SYNOVIALEN ZYTOKINEN UND PERIPHERER NERVENFUNKTION: EIN MOGLICHES ELEMENT BEI DER ENTSTEHUNG RADIKULARER SYNDROME

Translated title of the contribution: The interaction between synovial cytokines and peripheral nerve function: A possible element in the development of radicular syndromes

P. Wehling, C. H. Evans, K. P. Schulitz

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Cytokines of rabbit synovial origin were injected into 6 rats under the epineurium of the sciatic nerve. Five controls were injected with similar preparations lacking cytokines. After injection, rats were examined for a period of 7 days. For neurophysiological evaluation the tibial branch of the sciatic nerve was stimulated with supramaximal voltage impulses of constant duration. The responses were recorded at the dorsal root entry zone L1. F-wave latencies were recorded at the distal hind paw after stimulation of the tibial nerve. Filters were set at LF: 20 Hz, HF: 10 kHz. Synovial cytokines caused a significant decrease in amplitude and increase in latencies of the recorded nerve potentials. Our results indicate that interleukin-1, which is a major component of the synovial cytokine preparation, could play an important role in degenerative spine disease through a damaging effect on nerve function. This action would explain why radiculopathy and pain can develop without signs of nerve compression. The results are also relevant to patients suffering from osteoarthritis and rheumatoid arthritis.

Translated title of the contributionThe interaction between synovial cytokines and peripheral nerve function: A possible element in the development of radicular syndromes
Original languageGerman
Pages (from-to)442-446
Number of pages5
JournalZeitschrift fur Orthopadie und Ihre Grenzgebiete
Volume128
Issue number5
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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