The insulin-like growth factor/insulin system in epithelial ovarian cancer

Kimberly R. Kalli, Cheryl A Conover

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Ovarian cancer is the most lethal of the gynecologic malignancies, in part because the lack of striking symptoms in many women often results in diagnosis only after the disease has spread. In order to develop rational biologic or pharmacologic therapies, it is important to understand the biology of both normal and malignant ovarian epithelial cells. This review will summarize current knowledge of the expression and function of proteins in the insulin-like growth factor system in ovarian epithelium, including the peptide ligands, receptors, binding proteins, and binding protein proteases. All components of this complex regulatory system are present in the ovarian epithelium and may play important roles in regulating the normal biology of ovarian surface epithelial cells or the transformed phenotype of ovarian carcinoma cells.

Original languageEnglish (US)
JournalFrontiers in Bioscience
Volume8
StatePublished - 2003

Fingerprint

Somatomedins
Carrier Proteins
Epithelium
Epithelial Cells
Insulin
Peptide Receptors
Protein Binding
Ovarian Neoplasms
Peptide Hydrolases
Cells
Ligands
Carcinoma
Phenotype
Peptides
Neoplasms
Proteins
Ovarian epithelial cancer
Therapeutics

Keywords

  • Cancer
  • IGF Binding Proteins
  • IGF-I
  • IGF-I Receptor
  • IGF-II
  • IGF-II Receptor
  • IGFBP Proteases
  • Insulin Receptor
  • Ovary
  • Review
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

The insulin-like growth factor/insulin system in epithelial ovarian cancer. / Kalli, Kimberly R.; Conover, Cheryl A.

In: Frontiers in Bioscience, Vol. 8, 2003.

Research output: Contribution to journalArticle

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