The influence of varying inspired fractions of O 2 and CO 2 on the development of involuntary breathing movements during maximal apnoea

Toni Breskovic, Mihajlo Lojpur, Petra Zubin Maslov, Troy J. Cross, Jasenka Kraljevic, Marko Ljubkovic, Jasna Marinovic, Vladimir Ivancev, Bruce David Johnson, Zeljko Dujic

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The growing urge to breathe that occurs during breath-holding results in development of involuntary breathing movements (IBMs). The present study determined whether IBMs are initiated at critical levels of hypercapnia and/or hypoxia during maximal apnoea. Arterial blood gasses at the onset of IBM were monitored during maximal voluntary breath-holds. Eleven healthy men performed breath holds after breathing air, hyperoxic-normocapnia, hypoxic-normocapnia, and normoxic-hypercapnia. Pre-breathing of the gas mixtures facilitated the IBM onset, reducing the time-to-onset for ∼46% (hyperoxic condition) and for ∼80% (hypoxic condition) compared to the normoxic air breathing time. A strong correlation (R=0.83, P=0.002) between arterial partial pressure of CO 2 (PaCO2) at IBM onset after pre-breathing hyperoxic and hypercapnic gas mixtures was observed, suggesting the existence of a possible IBM PaCO2 threshold level of ∼6.5±0.5kPa. No clear "threshold" was observed for partial pressure of arterial O 2 (PaO2). However, we observed that IBM onset was influenced, in part, by an interaction between PaO2 and PaCO2 levels during maximal apnoea. This study demonstrated the complex interaction between arterial blood-gases and the physiological response to maximal breath holding.

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume181
Issue number2
DOIs
StatePublished - Apr 30 2012

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Dyskinesias
Apnea
Carbon Monoxide
Respiration
Partial Pressure
Breath Holding
Hypercapnia
Gases
Arterial Pressure
Air

Keywords

  • Apnoea
  • Diaphragm
  • Respiratory muscles
  • Ventilatory control

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

The influence of varying inspired fractions of O 2 and CO 2 on the development of involuntary breathing movements during maximal apnoea. / Breskovic, Toni; Lojpur, Mihajlo; Maslov, Petra Zubin; Cross, Troy J.; Kraljevic, Jasenka; Ljubkovic, Marko; Marinovic, Jasna; Ivancev, Vladimir; Johnson, Bruce David; Dujic, Zeljko.

In: Respiratory Physiology and Neurobiology, Vol. 181, No. 2, 30.04.2012, p. 228-233.

Research output: Contribution to journalArticle

Breskovic, T, Lojpur, M, Maslov, PZ, Cross, TJ, Kraljevic, J, Ljubkovic, M, Marinovic, J, Ivancev, V, Johnson, BD & Dujic, Z 2012, 'The influence of varying inspired fractions of O 2 and CO 2 on the development of involuntary breathing movements during maximal apnoea', Respiratory Physiology and Neurobiology, vol. 181, no. 2, pp. 228-233. https://doi.org/10.1016/j.resp.2012.03.007
Breskovic, Toni ; Lojpur, Mihajlo ; Maslov, Petra Zubin ; Cross, Troy J. ; Kraljevic, Jasenka ; Ljubkovic, Marko ; Marinovic, Jasna ; Ivancev, Vladimir ; Johnson, Bruce David ; Dujic, Zeljko. / The influence of varying inspired fractions of O 2 and CO 2 on the development of involuntary breathing movements during maximal apnoea. In: Respiratory Physiology and Neurobiology. 2012 ; Vol. 181, No. 2. pp. 228-233.
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