The influence of preservation injury on rejection in the hepatic transplant recipient

Todd K. Howard, Goran B.G. Klintmalm, Joseph B. Cofer, Bo S. Husberg, Robert M. Goldstein, Thomast A. Gonwa

Research output: Contribution to journalArticle

228 Scopus citations

Abstract

The records of 215 liver transplant recipients were reviewed and the degree of preservation injury was estimated by the initial aminotransferase levels. This was compared with the incidence of rejection found in the subsequent 30 days. Those with aspartate aminotransferase > 2000 U/L were classified as having severe preservation injury while those with ASAT < 600 U/L were considered to have had minimal preservation injury. There were no significant differences between these groups in recipient age, sex, cold ischemia time, preoperative physical status, panel-reactive antibodiesor cytotoxic crossmatch. The solution used for organ preservation and the donor age were the only factors that were found to be significantly different between the groups. Older donors were more common in the severe preservation injury group. Severe preservation injury was found more frequently in grafts preserved in Eurocollins solution and the group with minimal preservation injury more frequently used Wisconsin solution. There was significantly more rejection seen in the severe preservation injury group (71%) than in the group without preservation injury (33%), Although there was more rejection in the severe preservation injury group, the rejections were not more severe as judged by the need for multiple courses of therapy or the need for OKT3. Recurrent rejection was also not more frequent in either group. Graft survival was worse in the severe preservation injury group, with a significant increase in early graft loss, but no difference in the frequency of chronic rejection. Recovery of graft function was also delayed in the preservation injury group.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalTransplantation
Volume49
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Transplantation

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    Howard, T. K., Klintmalm, G. B. G., Cofer, J. B., Husberg, B. S., Goldstein, R. M., & Gonwa, T. A. (1990). The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation, 49(1), 103-107. https://doi.org/10.1097/00007890-199001000-00023