The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach

Tim Hsu Han Wang, Timothy R. Angeli, Shunichi Ishida, Peng Du, Armen Gharibans, Niranchan Paskaranandavadivel, Yohsuke Imai, Taimei Miyagawa, Thomas L. Abell, Gianrico Farrugia, Leo K. Cheng, Gregory O’Grady

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of interstitial cells of Cajal (ICC) has been associated with gastric dysfunction and is also observed during normal aging at ~13% reduction per decade. The impact of ICC loss on gastric slow wave conduction velocity is currently undefined. This study correlated human gastric slow wave velocity with ICC loss and aging. High-resolution gastric slow wave mapping data were screened from a database of 42 patients with severe gastric dysfunction (n = 20) and controls (n = 22). Correlations were performed between corpus slow wave conduction parameters (frequency, velocity, and amplitude) and corpus ICC counts in patients, and with age in controls. Physiological parameters were further integrated into computational models of gastric mixing. Patients: ICC count demonstrated a negative correlation with slow wave velocity in the corpus (i.e., higher velocities with reduced ICC; r2 =.55; p =.03). ICC count did not correlate with extracellular slow wave amplitude (p =.12) or frequency (p =.84). Aging: Age was positively correlated with slow wave velocity in the corpus (range: 25–74 years; r2 =.32; p =.02). Age did not correlate with extracellular slow wave amplitude (p =.40) or frequency (p =.34). Computational simulations demonstrated that the gastric emptying rate would increase at higher slow wave velocities. ICC loss and aging are associated with a higher slow wave velocity. The reason for these relationships is unexplained and merit further investigation. Increased slow wave velocity may modulate gastric emptying higher, although in gastroparesis other pathological factors must dominate to prevent emptying.

Original languageEnglish (US)
Article numbere14659
JournalPhysiological reports
Volume8
Issue number24
DOIs
StatePublished - Jan 2021

Keywords

  • aging
  • computational simulation
  • human
  • interstitial cells of Cajal (ICC)
  • slow wave velocity
  • stomach

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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