The influence of initial hemoglobin and blood pressure levels on results of radiation therapy for carcinoma of the prostate

Eamonn P. Dunphy, Ivy A Petersen, Richard S. Cox, Malcolm A. Bagshaw

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A group of 914 patients with carcinoma of the prostate treated by definitive radiotherapy at Stanford between 1956 and 1985 was studied. Of these, the initial hemoglobin level was recorded in 656 cases and the initial blood pressure in 760 cases. End-points studied in actuarial analyses were survival, disease-specific survival, local control, freedom from distant relapse, and occurrence of late intestinal complications. Although the anemic group (Hb < 13.5 g/dl) was correlated negatively with survival (p = 0.02), there was no correlation with disease-specific survival or local control. The conclusion was that anemia per se did not affect the outcome of radiation therapy. A pulse pressure ≥ 60 mm Hg was significantly correlated with worse survival (p = 0.01) and local control (p = 0.04), but no correlation was found between systolic and diastolic blood pressure and the end-points measured. Neither anemia nor hypertension were significantly correlated with late intestinal complications.

Original languageEnglish (US)
Pages (from-to)1173-1178
Number of pages6
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume16
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Anemia
  • Blood pressure
  • Prostate cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Fingerprint Dive into the research topics of 'The influence of initial hemoglobin and blood pressure levels on results of radiation therapy for carcinoma of the prostate'. Together they form a unique fingerprint.

  • Cite this