The influence of hepatitis C virus genotypes on the outcome of liver transplantation

Hugo E Vargas, T. Laskus, L. F. Wang, M. Radkowski, A. Poutous, R. Lee, J. A. Demetris, T. Gayowski, I. R. Marino, N. Singh, F. Dodson, A. Casavilla, J. J. Fung, Jorge Rakela

Research output: Contribution to journalArticle

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Abstract

Background: The aim of this study was to report the influence of hepatitis C virus (HCV) genotypes and HLA matches on the outcome of liver transplantation, hepatitis recurrence, and progression to cirrhosis after transplantation. Methods: HCV genotypes were determined from pretransplantation sere and/or liver explant tissues from 202 patients with HCV-related end-stage liver disease. One hundred fifty patients with known infecting genotype for whom posttransplantation biopsy specimens were available or who had normal results of liver injury tests constituted the group analyzed. Patients were followed up for up to 4.5 years. Hepatitis activity index scores at the time of disease recurrence were used to assess disease activity. Cirrhosis was diagnosed by using histological evidence. The number of HLA matches with respect to A, B, DR, and DQ loci was determined. Results: The rates of hepatitis recurrence were 25% and 75% at 1 year and 4 years, respectively; Kaplan-Meier survival analysis did not reveal significant differences between the infecting genotypes with respect to overall rates of survival or recurrence of hepatitis. At hepatitis recurrence, hepatitis activity index scores did not differ between the genotype groups. The distribution of infecting genotypes among the 7 patients who developed cirrhosis is reflective of pretransplantation distribution. Neither HLA site-specific nor total matches affected the rates of survival or disease recurrence. Conclusions: The infecting HCV genotype had no influence on the incidence or severity of recurrent hepatitis, rate of survival, or development of cirrhosis. HLA matching does not influence transplantation outcome for HCV-related disease.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalLiver Transplantation and Surgery
Volume4
Issue number1
StatePublished - 1998
Externally publishedYes

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Hepacivirus
Liver Transplantation
Hepatitis
Genotype
Recurrence
Fibrosis
Survival Rate
Transplantation
End Stage Liver Disease
Liver
Kaplan-Meier Estimate
Virus Diseases
Survival Analysis
Biopsy
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Hepatology
  • Surgery

Cite this

The influence of hepatitis C virus genotypes on the outcome of liver transplantation. / Vargas, Hugo E; Laskus, T.; Wang, L. F.; Radkowski, M.; Poutous, A.; Lee, R.; Demetris, J. A.; Gayowski, T.; Marino, I. R.; Singh, N.; Dodson, F.; Casavilla, A.; Fung, J. J.; Rakela, Jorge.

In: Liver Transplantation and Surgery, Vol. 4, No. 1, 1998, p. 22-27.

Research output: Contribution to journalArticle

Vargas, HE, Laskus, T, Wang, LF, Radkowski, M, Poutous, A, Lee, R, Demetris, JA, Gayowski, T, Marino, IR, Singh, N, Dodson, F, Casavilla, A, Fung, JJ & Rakela, J 1998, 'The influence of hepatitis C virus genotypes on the outcome of liver transplantation', Liver Transplantation and Surgery, vol. 4, no. 1, pp. 22-27.
Vargas, Hugo E ; Laskus, T. ; Wang, L. F. ; Radkowski, M. ; Poutous, A. ; Lee, R. ; Demetris, J. A. ; Gayowski, T. ; Marino, I. R. ; Singh, N. ; Dodson, F. ; Casavilla, A. ; Fung, J. J. ; Rakela, Jorge. / The influence of hepatitis C virus genotypes on the outcome of liver transplantation. In: Liver Transplantation and Surgery. 1998 ; Vol. 4, No. 1. pp. 22-27.
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abstract = "Background: The aim of this study was to report the influence of hepatitis C virus (HCV) genotypes and HLA matches on the outcome of liver transplantation, hepatitis recurrence, and progression to cirrhosis after transplantation. Methods: HCV genotypes were determined from pretransplantation sere and/or liver explant tissues from 202 patients with HCV-related end-stage liver disease. One hundred fifty patients with known infecting genotype for whom posttransplantation biopsy specimens were available or who had normal results of liver injury tests constituted the group analyzed. Patients were followed up for up to 4.5 years. Hepatitis activity index scores at the time of disease recurrence were used to assess disease activity. Cirrhosis was diagnosed by using histological evidence. The number of HLA matches with respect to A, B, DR, and DQ loci was determined. Results: The rates of hepatitis recurrence were 25{\%} and 75{\%} at 1 year and 4 years, respectively; Kaplan-Meier survival analysis did not reveal significant differences between the infecting genotypes with respect to overall rates of survival or recurrence of hepatitis. At hepatitis recurrence, hepatitis activity index scores did not differ between the genotype groups. The distribution of infecting genotypes among the 7 patients who developed cirrhosis is reflective of pretransplantation distribution. Neither HLA site-specific nor total matches affected the rates of survival or disease recurrence. Conclusions: The infecting HCV genotype had no influence on the incidence or severity of recurrent hepatitis, rate of survival, or development of cirrhosis. HLA matching does not influence transplantation outcome for HCV-related disease.",
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T1 - The influence of hepatitis C virus genotypes on the outcome of liver transplantation

AU - Vargas, Hugo E

AU - Laskus, T.

AU - Wang, L. F.

AU - Radkowski, M.

AU - Poutous, A.

AU - Lee, R.

AU - Demetris, J. A.

AU - Gayowski, T.

AU - Marino, I. R.

AU - Singh, N.

AU - Dodson, F.

AU - Casavilla, A.

AU - Fung, J. J.

AU - Rakela, Jorge

PY - 1998

Y1 - 1998

N2 - Background: The aim of this study was to report the influence of hepatitis C virus (HCV) genotypes and HLA matches on the outcome of liver transplantation, hepatitis recurrence, and progression to cirrhosis after transplantation. Methods: HCV genotypes were determined from pretransplantation sere and/or liver explant tissues from 202 patients with HCV-related end-stage liver disease. One hundred fifty patients with known infecting genotype for whom posttransplantation biopsy specimens were available or who had normal results of liver injury tests constituted the group analyzed. Patients were followed up for up to 4.5 years. Hepatitis activity index scores at the time of disease recurrence were used to assess disease activity. Cirrhosis was diagnosed by using histological evidence. The number of HLA matches with respect to A, B, DR, and DQ loci was determined. Results: The rates of hepatitis recurrence were 25% and 75% at 1 year and 4 years, respectively; Kaplan-Meier survival analysis did not reveal significant differences between the infecting genotypes with respect to overall rates of survival or recurrence of hepatitis. At hepatitis recurrence, hepatitis activity index scores did not differ between the genotype groups. The distribution of infecting genotypes among the 7 patients who developed cirrhosis is reflective of pretransplantation distribution. Neither HLA site-specific nor total matches affected the rates of survival or disease recurrence. Conclusions: The infecting HCV genotype had no influence on the incidence or severity of recurrent hepatitis, rate of survival, or development of cirrhosis. HLA matching does not influence transplantation outcome for HCV-related disease.

AB - Background: The aim of this study was to report the influence of hepatitis C virus (HCV) genotypes and HLA matches on the outcome of liver transplantation, hepatitis recurrence, and progression to cirrhosis after transplantation. Methods: HCV genotypes were determined from pretransplantation sere and/or liver explant tissues from 202 patients with HCV-related end-stage liver disease. One hundred fifty patients with known infecting genotype for whom posttransplantation biopsy specimens were available or who had normal results of liver injury tests constituted the group analyzed. Patients were followed up for up to 4.5 years. Hepatitis activity index scores at the time of disease recurrence were used to assess disease activity. Cirrhosis was diagnosed by using histological evidence. The number of HLA matches with respect to A, B, DR, and DQ loci was determined. Results: The rates of hepatitis recurrence were 25% and 75% at 1 year and 4 years, respectively; Kaplan-Meier survival analysis did not reveal significant differences between the infecting genotypes with respect to overall rates of survival or recurrence of hepatitis. At hepatitis recurrence, hepatitis activity index scores did not differ between the genotype groups. The distribution of infecting genotypes among the 7 patients who developed cirrhosis is reflective of pretransplantation distribution. Neither HLA site-specific nor total matches affected the rates of survival or disease recurrence. Conclusions: The infecting HCV genotype had no influence on the incidence or severity of recurrent hepatitis, rate of survival, or development of cirrhosis. HLA matching does not influence transplantation outcome for HCV-related disease.

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