The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats

Sang Ho Kim, Hong Kim, Sung Soo Kim, Mal Soon Shin, Hyun Kyung Chang, Taeck Hyun Lee, Mi-Hyeon D Jang, Min Chul Shin, Hee Hyuk Lee, Young Pyo Kim, Chang Ju Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

c-Fos has been used as a neuronal activity marker. Here, we examined the influence of age on the treadmill running-induced c-Fos expression in rat hippocampus. Rats of exercise groups were forced to run on treadmill for 30 min once a day for 5 consecutive days. Without exercise, c-Fos expression was highest in 8-week old rats. Treadmill exercise significantly enhanced the c-Fos expression in the hippocampus of rats in all ages. In the CA region, the increase of the c-Fos expression by treadmill exercise was highest in 4-week old rats. In the dentate gyrus, the increase of the c-Fos expression by treadmill exercise was highest in 62-week old rats. The data show that age is an important factor for the regulation of the c-Fos expression in the hippocampus and that the ability of the treadmill exercise enhancing the c-Fos expression is dependent on age status.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalNeuroscience Research Communications
Volume35
Issue number1
DOIs
StatePublished - Jul 2004
Externally publishedYes

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Hippocampus
Dentate Gyrus
Running

Keywords

  • Age
  • c-Fos
  • Hippocampus
  • Immunohistochemistry
  • Treadmill exercise

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kim, S. H., Kim, H., Kim, S. S., Shin, M. S., Chang, H. K., Lee, T. H., ... Kim, C. J. (2004). The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats. Neuroscience Research Communications, 35(1), 41-50. https://doi.org/10.1002/nrc.20018

The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats. / Kim, Sang Ho; Kim, Hong; Kim, Sung Soo; Shin, Mal Soon; Chang, Hyun Kyung; Lee, Taeck Hyun; Jang, Mi-Hyeon D; Shin, Min Chul; Lee, Hee Hyuk; Kim, Young Pyo; Kim, Chang Ju.

In: Neuroscience Research Communications, Vol. 35, No. 1, 07.2004, p. 41-50.

Research output: Contribution to journalArticle

Kim, SH, Kim, H, Kim, SS, Shin, MS, Chang, HK, Lee, TH, Jang, M-HD, Shin, MC, Lee, HH, Kim, YP & Kim, CJ 2004, 'The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats', Neuroscience Research Communications, vol. 35, no. 1, pp. 41-50. https://doi.org/10.1002/nrc.20018
Kim, Sang Ho ; Kim, Hong ; Kim, Sung Soo ; Shin, Mal Soon ; Chang, Hyun Kyung ; Lee, Taeck Hyun ; Jang, Mi-Hyeon D ; Shin, Min Chul ; Lee, Hee Hyuk ; Kim, Young Pyo ; Kim, Chang Ju. / The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats. In: Neuroscience Research Communications. 2004 ; Vol. 35, No. 1. pp. 41-50.
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