The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats

Sang Ho Kim, Hong Kim, Sung Soo Kim, Mal Soon Shin, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Hee Hyuk Lee, Young Pyo Kim, Chang Ju Kim

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

c-Fos has been used as a neuronal activity marker. Here, we examined the influence of age on the treadmill running-induced c-Fos expression in rat hippocampus. Rats of exercise groups were forced to run on treadmill for 30 min once a day for 5 consecutive days. Without exercise, c-Fos expression was highest in 8-week old rats. Treadmill exercise significantly enhanced the c-Fos expression in the hippocampus of rats in all ages. In the CA region, the increase of the c-Fos expression by treadmill exercise was highest in 4-week old rats. In the dentate gyrus, the increase of the c-Fos expression by treadmill exercise was highest in 62-week old rats. The data show that age is an important factor for the regulation of the c-Fos expression in the hippocampus and that the ability of the treadmill exercise enhancing the c-Fos expression is dependent on age status.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalNeuroscience Research Communications
Volume35
Issue number1
DOIs
StatePublished - Jul 1 2004

Keywords

  • Age
  • Hippocampus
  • Immunohistochemistry
  • Treadmill exercise
  • c-Fos

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kim, S. H., Kim, H., Kim, S. S., Shin, M. S., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lee, H. H., Kim, Y. P., & Kim, C. J. (2004). The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats. Neuroscience Research Communications, 35(1), 41-50. https://doi.org/10.1002/nrc.20018