Abstract
c-Fos has been used as a neuronal activity marker. Here, we examined the influence of age on the treadmill running-induced c-Fos expression in rat hippocampus. Rats of exercise groups were forced to run on treadmill for 30 min once a day for 5 consecutive days. Without exercise, c-Fos expression was highest in 8-week old rats. Treadmill exercise significantly enhanced the c-Fos expression in the hippocampus of rats in all ages. In the CA region, the increase of the c-Fos expression by treadmill exercise was highest in 4-week old rats. In the dentate gyrus, the increase of the c-Fos expression by treadmill exercise was highest in 62-week old rats. The data show that age is an important factor for the regulation of the c-Fos expression in the hippocampus and that the ability of the treadmill exercise enhancing the c-Fos expression is dependent on age status.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-50 |
| Number of pages | 10 |
| Journal | Neuroscience Research Communications |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2004 |
Keywords
- Age
- Hippocampus
- Immunohistochemistry
- Treadmill exercise
- c-Fos
ASJC Scopus subject areas
- Neuroscience(all)