The induction of IL-1 by freeze-dried ethylene oxide-treated bone-patellar tendon-bone allograft wear particles: An in vitro study

V. J. Silvaggio, F. H. Fu, H. I. Georgescu, C. H. Evans

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

There have been recent reports of adverse clinical results with freeze-dried ethylene oxide-treated bone-patellar tendon-bone (FD-ETO-BPTB) allografts used in anterior cruciate ligament (ACL) reconstruction. Ethylene oxide and its residues were implicated as the cause of many of the failures. Wear particles generated from both freeze-dried ethylene oxidetreated and deep frozen bone-patellar tendon-bone (DF-BPTB) allografts were placed in culture with lapine synoviocytes. The resulting synovialconditioned media were then assayed for interleukin-1 (IL-1) content. IL-1 is a potent mediator of tissue inflammation. FD-ETO-BPTB wear particles generated statistically significant levels of IL-1 when compared with both a negative control and DF-BPTB wear particles.

Original languageEnglish (US)
Pages (from-to)82-86
Number of pages5
JournalArthroscopy
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1993

Keywords

  • Anterior cruciate ligament
  • Ethylene oxide
  • Interleukin-1

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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