The IncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer

John R. Prensner, Anirban Sahu, Matthew K. Iyer, Rohit Malik, Benjamin Chandler, Irfan A. Asangani, Anton Poliakov, Ismael A. Vergara, Mohammed Alshalalfa, Robert B. Jenkins, Elai Davicioni, Felix Y. Feng, Arul M. Chinnaiyan

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Long noncoding RNAs (IncRNAs) are increasingly implicated in cancer biology, contributing to essential cancer cell functions such as proliferation, invasion, and metastasis. In prostate cancer, several IncRNAs have been nominated as critical actors in disease pathogenesis. Among these, expression of PCGEM1 and PRNCR1 has been identified as a possible component in disease progression through the coordination of androgen receptor (AR) signaling (Yang et al., Nature 2013, see ref. [1]). However, concerns regarding the robustness of these findings have been suggested. Here, we sought to evaluate whether PCGEM1 and PRNCR1 are associated with prostate cancer. Through a comprehensive analysis of RNA-sequencing data (RNA-seq), we find evidence that PCGEM1 but not PRNCR1 is associated with prostate cancer. We employ a large cohort of >230 high-risk prostate cancer patients with long-term outcomes data to show that, in contrast to prior reports, neither gene is associated with poor patient outcomes. We further observe no evidence that PCGEM1 nor PRNCR1 interact with AR, and neither gene is a component of AR signaling. Thus, we conclusively demonstrate that PCGEM1 and PRNCR1 are not prognostic IncRNAs in prostate cancer and we refute suggestions that these IncRNAs interact in AR signaling.

Original languageEnglish (US)
Pages (from-to)1434-1438
Number of pages5
JournalOncotarget
Volume5
Issue number6
DOIs
StatePublished - 2014

Keywords

  • Androgen receptor
  • Long noncoding RNA
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology

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    Prensner, J. R., Sahu, A., Iyer, M. K., Malik, R., Chandler, B., Asangani, I. A., Poliakov, A., Vergara, I. A., Alshalalfa, M., Jenkins, R. B., Davicioni, E., Feng, F. Y., & Chinnaiyan, A. M. (2014). The IncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer. Oncotarget, 5(6), 1434-1438. https://doi.org/10.18632/oncotarget.1846