@article{3b1724aa0b1c4ff587947774c6abf171,
title = "The incidence of MCI differs by subtype and is higher in men: The Mayo Clinic study of aging",
abstract = "Objective: Although incidence rates for mild cognitive impairment (MCI) have been reported, few studies were specifically designed to measure the incidence of MCI and its subtypes using published criteria. We estimated the incidence of amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in men and women separately. Methods: A population-based prospective cohort of Olmsted County, MN, residents ages 70-89 years on October 1, 2004, underwent baseline and 15-month interval evaluations that included the Clinical Dementia Rating scale, a neurologic evaluation, and neuropsychological testing. A panel of examiners blinded to previous diagnoses reviewed data at each serial evaluation to assess cognitive status according to published criteria. Results: Among 1,450 subjects who were cognitively normal at baseline, 296 developed MCI. The age-and sex-standardized incidence rate of MCI was 63.6 (per 1,000 person-years) overall, and was higher in men (72.4) than women (57.3) and for aMCI (37.7) than naMCI (14.7). The incidence rate of aMCI was higher for men (43.9) than women (33.3), and for subjects with ≤12 years of education (42.6) than higher education (32.5). The risk of naMCI was also higher for men (20.0) than women (10.9) and for subjects with ≤12 years of education (20.3) than higher education (10.2). Conclusions: The incidence rates for MCI are substantial. Differences in incidence rates by clinical subtype and by sex suggest that risk factors for MCI should be investigated separately for aMCI and naMCI, and in men and women.",
author = "Roberts, {R. O.} and Geda, {Y. E.} and Knopman, {D. S.} and Cha, {R. H.} and Pankratz, {V. S.} and Boeve, {B. F.} and Tangalos, {E. G.} and Ivnik, {R. J.} and Rocca, {W. A.} and Petersen, {R. C.}",
note = "Funding Information: Dr. Roberts receives research support from the NIH and Abbott. Dr. Geda receives research support from the NIH, Mayo CTSA, the RWJ Foundation (Harold Amos Scholar), and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program. Dr. Knopman serves as Deputy Editor for Neurology {\textregistered}; has served on a data safety monitoring board for Eli Lilly and Company; has served as a consultant for Elan/Janssen AI; is an investigator in clinical trials sponsored by Elan/Janssen AI, Baxter International Inc., and Forest Laboratories, Inc.; and receives research support from the NIH. R.H. Cha and Dr. Pankratz report no disclosures. Dr. Boeve has served as a consultant to GE Healthcare; receives publishing royalties for The Behavioral Neurology of Dementia (Cambridge University Press, 2009); and receives research support from Cephalon, Inc., Allon Therapeutics, Inc., the NIH/NIA, the Alzheimer's Association, and the Mangurian Foundation. Dr. Tangalos serves on a Data Safety Monitoring Board for Eli Lilly and Company; serves as a consultant for Purdue Pharma and Amgen; serves on the editorial boards of MD Net Guide, Journal of the American Medical Directors Association, and IM News; has received honoraria for slide development from Takeda Pharmaceutical Company Limited, Novartis, and Ortho Biotech Products, L.P.; receives research support from Baxter International, Inc. and Elan Corporation; and serves as a consultant to Novartis. Dr. Ivnik serves on the editorial boards of The Clinical Neuropsychologist and Aging, Neuropsychology, and Cognition ; receives publishing royalties for Clinical Interpretation of the WAIS-III and WMS-III (Academic Press, 2003); and receives research support from the NIH/NIA. Dr. Rocca receives research support from the NIH. Dr. Petersen serves on scientific advisory boards for the Alzheimer's Association, the National Advisory Council on Aging (NIA), Elan/Janssen AI, Pfizer Inc (Wyeth), and GE Healthcare; receives publishing royalties from Mild Cognitive Impairment (Oxford University Press, 2003); serves as a consultant for Elan/Janssen AI and GE Healthcare; and receives research support from the NIH/NIA.",
year = "2012",
month = jan,
day = "31",
doi = "10.1212/WNL.0b013e3182452862",
language = "English (US)",
volume = "78",
pages = "342--351",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",
}