The incidence and prevalence of myoclonus in Olmsted County, Minnesota

John Nathaniel Caviness, Loren I. Alving, Demetrius M. Maraganore, Rita A. Black, Shannon K. Mcüonnell, Walter A Rocca

Research output: Contribution to journalArticle

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Abstract

Objective: To study the incidence and prevalence of diagnosed myoclonus in Olmsted County, Minnesota. Little is known about the frequency and distribution of myoclonus in the general population. Design: Descriptive study with case ascertainment through a records-linkage system. Patients and Methods: We used a medical records-linkage system to identify all subjects whose records contained documentation of myoclonus or of diseases known to exhibit myoclonus. The records of all potential patients were reviewed by a neurologist, and only patients with pathologic and persistent myoclonus were included. Population denominators were derived from census data. Results: The average annual incidence rate of pathologic and persistent myoclonus for 1976 through 1990 was 1.3 cases per 100,000 person-years. The rate increased with advancing age and was consistently higher in men. Symptomatic myoclonus was the most common type, followed by epileptic and essential myoclonus; dementing diseases were the most common cause of symptomatic myoclonus. The lifetime prevalence of myoclonus, as of January 1, 1990, was 8.6 cases per 100,000 population, and the prevalence increased with advancing age. Conclusion: Although our figures are probably underestimated, they are the first attempt, to our knowledge, to measure myoclonus morbidity in the general population. We found clinical features and age and sex distributions different from those previously described in clinical series.

Original languageEnglish (US)
Pages (from-to)565-569
Number of pages5
JournalMayo Clinic Proceedings
Volume74
Issue number6
StatePublished - 1999

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Myoclonus
Incidence
Population
Medical Record Linkage
Sex Distribution
Age Distribution
Censuses
Documentation
Cohort Studies
Cross-Sectional Studies
Morbidity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Caviness, J. N., Alving, L. I., Maraganore, D. M., Black, R. A., Mcüonnell, S. K., & Rocca, W. A. (1999). The incidence and prevalence of myoclonus in Olmsted County, Minnesota. Mayo Clinic Proceedings, 74(6), 565-569.

The incidence and prevalence of myoclonus in Olmsted County, Minnesota. / Caviness, John Nathaniel; Alving, Loren I.; Maraganore, Demetrius M.; Black, Rita A.; Mcüonnell, Shannon K.; Rocca, Walter A.

In: Mayo Clinic Proceedings, Vol. 74, No. 6, 1999, p. 565-569.

Research output: Contribution to journalArticle

Caviness, JN, Alving, LI, Maraganore, DM, Black, RA, Mcüonnell, SK & Rocca, WA 1999, 'The incidence and prevalence of myoclonus in Olmsted County, Minnesota', Mayo Clinic Proceedings, vol. 74, no. 6, pp. 565-569.
Caviness JN, Alving LI, Maraganore DM, Black RA, Mcüonnell SK, Rocca WA. The incidence and prevalence of myoclonus in Olmsted County, Minnesota. Mayo Clinic Proceedings. 1999;74(6):565-569.
Caviness, John Nathaniel ; Alving, Loren I. ; Maraganore, Demetrius M. ; Black, Rita A. ; Mcüonnell, Shannon K. ; Rocca, Walter A. / The incidence and prevalence of myoclonus in Olmsted County, Minnesota. In: Mayo Clinic Proceedings. 1999 ; Vol. 74, No. 6. pp. 565-569.
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