The importance of placebo in headache research

H. C. Diener, C. F. Schorn, U. Bingel, D. W. Dodick

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

The best way to appreciate the efficacy of drug and behavioural therapy in the acute and prophylactic treatment of headache is to perform placebo-controlled randomized trials. In order to plan and conduct these studies in the most appropriate way, it is desirable to know which factors influence the placebo response. This paper reviews factors which influence the placebo response in clinical trials, such as expectation, blinding, route of application of drugs and age, gender and geographical distribution. Response rates of placebo in the treatment of acute headache episodes are higher than in headache prophylaxis. Invasive procedures such as injections have a higher placebo response compared with oral drugs. Variables known to influence the placebo response have to be taken into consideration to calculate properly the power of planned randomized trials.

Original languageEnglish (US)
Pages (from-to)1003-1011
Number of pages9
JournalCephalalgia
Volume28
Issue number10
DOIs
StatePublished - Oct 1 2008

Keywords

  • Clinical trials
  • Headache
  • Imaging
  • Migraine
  • Placebo

ASJC Scopus subject areas

  • Clinical Neurology

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