The importance of matrix metalloproteinase-3 in respiratory disorders

Cory M. Yamashita, Derek C Radisky, Yael Aschner, Gregory P. Downey

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The matrix metalloproteinases (MMPs) encompass a family of zinc-dependent endopeptidases that are secreted into the extracellular environment or remain bound to the cell surface. While MMPs were initially identified based on their ability to degrade collagen and other components of the extracellular matrix, recent studies indicate that their non-degradative functions are physiologically paramount. In particular, MMPs are now known to participate in diverse physiological processes that control key aspects of inflammatory and immune responses and neoplasia, in part by selective triggering of cellular signaling pathways via limited proteolytic processing of extracellular and membrane-associated proteins, including cytokines and cell surface receptors. Herein, we focus on the unique roles of MMP-3 (stromelysin-1) in acute lung injury and repair, pulmonary fibrosis, and lung cancer.

Original languageEnglish (US)
Pages (from-to)411-421
Number of pages11
JournalExpert Review of Respiratory Medicine
Volume8
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Matrix Metalloproteinase 3
Matrix Metalloproteinases
Lung Neoplasms
Physiological Phenomena
Endopeptidases
Pulmonary Fibrosis
Acute Lung Injury
Cell Surface Receptors
Extracellular Matrix
Zinc
Membrane Proteins
Collagen
Cytokines
Neoplasms

Keywords

  • Acute lung injury
  • Acute respiratory distress syndrome
  • Epithelial mesenchymal transformation
  • Extracellular matrix
  • Lung cancer
  • Proteinase
  • Proteolytic processing
  • Pulmonary fibrosis
  • Signal transduction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

The importance of matrix metalloproteinase-3 in respiratory disorders. / Yamashita, Cory M.; Radisky, Derek C; Aschner, Yael; Downey, Gregory P.

In: Expert Review of Respiratory Medicine, Vol. 8, No. 4, 2014, p. 411-421.

Research output: Contribution to journalArticle

Yamashita, Cory M. ; Radisky, Derek C ; Aschner, Yael ; Downey, Gregory P. / The importance of matrix metalloproteinase-3 in respiratory disorders. In: Expert Review of Respiratory Medicine. 2014 ; Vol. 8, No. 4. pp. 411-421.
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