The importance of FLT3 mutational analysis in acute myeloid leukemia

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Activating mutations in FMS-like tyrosine kinase 3 (FLT3), including internal tandem duplications (ITDs) and tyrosine kinase domain (TKD) mutations, are common in patients with acute myeloid leukemia (AML). FLT3-ITD is a negative prognostic factor that remains prognostically relevant even after intensive chemotherapy and/or stem cell transplant. FLT3 testing was historically viewed as being purely prognostic; however, with the advent of FLT3 inhibitors, it will likely be seen as both prognostic and predictive. The multikinase inhibitor midostaurin, in combination with chemotherapy, is the first targeted agent to significantly prolong survival in patients with newly diagnosed FLT3-mutated AML and was recently approved by health authorities. Recently, the European LeukemiaNet recommended FLT3 testing (both TKD and ITD) for all patients with AML, with results required within 3 days. The need for optimized, multigene platform testing incorporating FLT3 mutations will increase as knowledge of interactions between FLT3 and other myeloid-relevant mutations grows.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - Nov 23 2017

Keywords

  • AML
  • FLT3 testing
  • FLT3 tyrosine kinase inhibitor
  • predictive marker
  • prognostic

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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