The impact of race, ethnicity, age and sex on clinical outcome in chronic lymphocytic leukemia

A comprehensive Surveillance, Epidemiology, and End Results analysis in the modern era

Chadi Nabhan, Briseis Aschebrook-Kilfoy, Brian C H Chiu, Sonali M. Smith, Tait D. Shanafelt, Andrew M. Evens, Neil Elliot Kay

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To analyze racial, ethnic, sex and age disparities in chronic lymphocytic leukemia (CLL), we examined population-based overall survival (OS) data from Surveillance, Epidemiology, and End Results (SEER)-13 (1992-2009) across various races/ethnicities over two consecutive 9-year periods: era 1 (1992-2000) and era 2 (2001-2009). We analyzed 28 590 patients (whites: 24 438, blacks: 1954, Hispanics: 1389 and Asians/Pacific Islanders [A/PI]: 809). A higher proportion of whites were aged > 80 years (22% vs. 17% [Hispanics], 16% [blacks], 16% [A/PI]; p < 0.001). Higher socioeconomic status (SES) was also identified for A/PI and whites compared with blacks and Hispanics (p < 0.001). OS for all patients improved at 5 years (66% vs. 60%, p < 0.0001) and was significant in all races/ethnicities except A/PI. Patients of higher SES had better outcomes than others independent of era, but both SES classes experienced relative improvement in their OS across eras. The OS of patients with CLL has improved in the modern era but racial/ethnic, gender and SES differences persist, warranting further investigation.

Original languageEnglish (US)
Pages (from-to)2778-2784
Number of pages7
JournalLeukemia and Lymphoma
Volume55
Issue number12
DOIs
StatePublished - Dec 1 2014

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B-Cell Chronic Lymphocytic Leukemia
Social Class
Epidemiology
Hispanic Americans
Survival
Population

Keywords

  • Age disparity
  • Chronic lymphocytic leukemia
  • Ethnic disparity
  • Gender disparity
  • Racial disparity
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

The impact of race, ethnicity, age and sex on clinical outcome in chronic lymphocytic leukemia : A comprehensive Surveillance, Epidemiology, and End Results analysis in the modern era. / Nabhan, Chadi; Aschebrook-Kilfoy, Briseis; Chiu, Brian C H; Smith, Sonali M.; Shanafelt, Tait D.; Evens, Andrew M.; Kay, Neil Elliot.

In: Leukemia and Lymphoma, Vol. 55, No. 12, 01.12.2014, p. 2778-2784.

Research output: Contribution to journalArticle

Nabhan, Chadi ; Aschebrook-Kilfoy, Briseis ; Chiu, Brian C H ; Smith, Sonali M. ; Shanafelt, Tait D. ; Evens, Andrew M. ; Kay, Neil Elliot. / The impact of race, ethnicity, age and sex on clinical outcome in chronic lymphocytic leukemia : A comprehensive Surveillance, Epidemiology, and End Results analysis in the modern era. In: Leukemia and Lymphoma. 2014 ; Vol. 55, No. 12. pp. 2778-2784.
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