The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

Karen L. Huyck, Carolien I M Panhuysen, Karen T. Cuenco, Jingmei Zhang, Hilary Goldhammer, Emlyn S. Jones, Priya Somasundaram, Allison M. Lynch, Bernard L. Harlow, Hang Lee, Elizabeth A Stewart, Cynthia C. Morton

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68 Scopus citations

Abstract

Objective: The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis. Study Design: We collected and analyzed epidemiologic data from 285 sister pairs diagnosed with UL. Risk factors for UL-related outcomes were compared among black (n = 73) and white (n = 212) sister pairs using univariate and multivariate regression models. Results: Black women reported an average age at diagnosis of 5.3 years younger (SE, 1.1; P < .001) and were more likely to report severe disease (odds ratio, 5.22; 95% confidence interval, 1.99-13.7, P < .001) than white women of similar socioeconomic status. Conclusion: Self-reported race is a significant factor in the severity of UL among women with a family history of UL. Differences in disease presentation between races likely reflect underlying genetic heterogeneity. The affected sister-pair study design can address both epidemiological and genetic hypotheses about UL.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume198
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

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Keywords

  • family study
  • fibroids
  • racial differences
  • symptom severity
  • uterine leiomyomata

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Huyck, K. L., Panhuysen, C. I. M., Cuenco, K. T., Zhang, J., Goldhammer, H., Jones, E. S., Somasundaram, P., Lynch, A. M., Harlow, B. L., Lee, H., Stewart, E. A., & Morton, C. C. (2008). The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. American Journal of Obstetrics and Gynecology, 198(2). https://doi.org/10.1016/j.ajog.2007.05.038