The impact of perioperative blood transfusion on survival after nephrectomy for non-metastatic renal cell carcinoma (RCC)

Brian J. Linder, R. Houston Thompson, Bradley C. Leibovich, John C. Cheville, Christine M. Lohse, Dennis A. Gastineau, Stephen A. Boorjian

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Objective To evaluate the association of perioperative blood transfusion (PBT) with survival after nephrectomy. Patients and Methods We identified 2318 patients who underwent partial or radical nephrectomy at Mayo Clinic between 1990 and 2006. PBT was defined as transfusion of allogenic red blood cells during surgery or postoperative hospitalisation. Survival was estimated using the Kaplan-Meier method and compared with the log-rank test. Cox proportional hazards regression models were used to evaluate the association of PBT with outcome. Results In all, 498 patients (21%) received a PBT. The median (interquartile range) number of units transfused was 3 (2, 5). Patients receiving a PBT were significantly older at surgery (P < 0.001), more likely to be female (P < 0.001), with more frequent symptomatic presentation (P < 0.001), worse Eastern Cooperative Oncology Group performance status (P < 0.001), and more frequent adverse pathological features, such as high nuclear grade (P < 0.001), locally-advanced tumour stage (P < 0.001) and lymph node invasion (P < 0.001). The median follow-up was 9.1 years. Receipt of a PBT was associated with adverse 5-year cancer-specific (68% vs 92%; P < 0.001) and overall (56% vs 82%; P < 0.001) survival. On multivariate analyses, PBT remained associated with higher risk of death from any cause (hazard ratio [HR] 1.23; P = 0.02). Among patients who received a PBT, an increasing number of units transfused was independently associated with increased all-cause mortality (HR 1.08; P = 0.001). Conclusion PBT is associated with a significantly increased risk of mortality after nephrectomy. While external validation is needed, continued efforts to minimise the use of blood products in these patients are warranted.

Original languageEnglish (US)
Pages (from-to)368-374
Number of pages7
JournalBJU international
Volume114
Issue number3
DOIs
StatePublished - Jan 1 2014

Keywords

  • kidney cancer
  • outcomes
  • renal cell carcinoma (RCC)
  • transfusion

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'The impact of perioperative blood transfusion on survival after nephrectomy for non-metastatic renal cell carcinoma (RCC)'. Together they form a unique fingerprint.

  • Cite this

    Linder, B. J., Thompson, R. H., Leibovich, B. C., Cheville, J. C., Lohse, C. M., Gastineau, D. A., & Boorjian, S. A. (2014). The impact of perioperative blood transfusion on survival after nephrectomy for non-metastatic renal cell carcinoma (RCC). BJU international, 114(3), 368-374. https://doi.org/10.1111/bju.12535