The impact of glucose control on coronary plaque composition in patients with diabetes mellitus

Dong Ju Yang, Moo Sik Lee, Wan Ho Kim, Hyun Woong Park, Ki Hong Kim, Taek Geun Kwon, Sang Wook Kim, Charanjit S. Rihal, Amir Lerman, Jang Ho Bae

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Patients with diabetes mellitus (DM) are known to have large necrotic core in their coronary plaque compared to non-DM patients. We assessed coronary plaque composition in patients with angina and with/without DM according to glucose control. Methods: Study subjects consisted of 114 non-DM patients, 14 well-controlled DM patients (hemoglobin A1c [HbA1c] <7.0%), and 37 poorly controlled DM patients (HbA1c ≥7%) who underwent virtual histology intravascular ultrasound (VH-IVUS) examinations of culprit lesions. Results: The DM patients had longer lesion length (20.2 ± 7.8 mm vs 17.0 ± 7.3 mm; P≤.013) than non-DM patients. The plaque volume was highest in the poorly-controlled DM patients (188.9 ± 92.6 mm) compared with the non-DM patients (144.1 ± 92.3 mm; P≤.011) and the well-controlled DM patients (151.7 ± 82.4 mm; P≤.194). The well-controlled DM patients had less dense calcium (0.33 ± 0.14 mm/mm vs 0.71 ± 0.60 mm/mm; P≤.020) and less necrotic core (0.71 ± 0.48 mm/mm vs 1.30 ± 0.94 mm/mm; P≤.029) than the poorly-controlled DM patients and had similar amounts of dense calcium and necrotic core with non-DM patients, whereas fibrous and fibro-fatty volume showed no significant differences among the groups. Conclusion: Coronary plaque composition and plaque volume in well-controlled DM patients are similar to those in non-DM patients and both groups had less dense calcium and necrotic core volume than the poorly-controlled DM patients. These findings suggest hyperglycemia control is important in DM patients with angina.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalJournal of Invasive Cardiology
Volume25
Issue number3
StatePublished - Mar 2013
Externally publishedYes

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Diabetes Mellitus
Glucose
Calcium
Hemoglobins
Hyperglycemia
Histology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Yang, D. J., Lee, M. S., Kim, W. H., Park, H. W., Kim, K. H., Kwon, T. G., ... Bae, J. H. (2013). The impact of glucose control on coronary plaque composition in patients with diabetes mellitus. Journal of Invasive Cardiology, 25(3), 137-141.

The impact of glucose control on coronary plaque composition in patients with diabetes mellitus. / Yang, Dong Ju; Lee, Moo Sik; Kim, Wan Ho; Park, Hyun Woong; Kim, Ki Hong; Kwon, Taek Geun; Kim, Sang Wook; Rihal, Charanjit S.; Lerman, Amir; Bae, Jang Ho.

In: Journal of Invasive Cardiology, Vol. 25, No. 3, 03.2013, p. 137-141.

Research output: Contribution to journalArticle

Yang, DJ, Lee, MS, Kim, WH, Park, HW, Kim, KH, Kwon, TG, Kim, SW, Rihal, CS, Lerman, A & Bae, JH 2013, 'The impact of glucose control on coronary plaque composition in patients with diabetes mellitus', Journal of Invasive Cardiology, vol. 25, no. 3, pp. 137-141.
Yang DJ, Lee MS, Kim WH, Park HW, Kim KH, Kwon TG et al. The impact of glucose control on coronary plaque composition in patients with diabetes mellitus. Journal of Invasive Cardiology. 2013 Mar;25(3):137-141.
Yang, Dong Ju ; Lee, Moo Sik ; Kim, Wan Ho ; Park, Hyun Woong ; Kim, Ki Hong ; Kwon, Taek Geun ; Kim, Sang Wook ; Rihal, Charanjit S. ; Lerman, Amir ; Bae, Jang Ho. / The impact of glucose control on coronary plaque composition in patients with diabetes mellitus. In: Journal of Invasive Cardiology. 2013 ; Vol. 25, No. 3. pp. 137-141.
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abstract = "Background: Patients with diabetes mellitus (DM) are known to have large necrotic core in their coronary plaque compared to non-DM patients. We assessed coronary plaque composition in patients with angina and with/without DM according to glucose control. Methods: Study subjects consisted of 114 non-DM patients, 14 well-controlled DM patients (hemoglobin A1c [HbA1c] <7.0{\%}), and 37 poorly controlled DM patients (HbA1c ≥7{\%}) who underwent virtual histology intravascular ultrasound (VH-IVUS) examinations of culprit lesions. Results: The DM patients had longer lesion length (20.2 ± 7.8 mm vs 17.0 ± 7.3 mm; P≤.013) than non-DM patients. The plaque volume was highest in the poorly-controlled DM patients (188.9 ± 92.6 mm) compared with the non-DM patients (144.1 ± 92.3 mm; P≤.011) and the well-controlled DM patients (151.7 ± 82.4 mm; P≤.194). The well-controlled DM patients had less dense calcium (0.33 ± 0.14 mm/mm vs 0.71 ± 0.60 mm/mm; P≤.020) and less necrotic core (0.71 ± 0.48 mm/mm vs 1.30 ± 0.94 mm/mm; P≤.029) than the poorly-controlled DM patients and had similar amounts of dense calcium and necrotic core with non-DM patients, whereas fibrous and fibro-fatty volume showed no significant differences among the groups. Conclusion: Coronary plaque composition and plaque volume in well-controlled DM patients are similar to those in non-DM patients and both groups had less dense calcium and necrotic core volume than the poorly-controlled DM patients. These findings suggest hyperglycemia control is important in DM patients with angina.",
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AU - Park, Hyun Woong

AU - Kim, Ki Hong

AU - Kwon, Taek Geun

AU - Kim, Sang Wook

AU - Rihal, Charanjit S.

AU - Lerman, Amir

AU - Bae, Jang Ho

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N2 - Background: Patients with diabetes mellitus (DM) are known to have large necrotic core in their coronary plaque compared to non-DM patients. We assessed coronary plaque composition in patients with angina and with/without DM according to glucose control. Methods: Study subjects consisted of 114 non-DM patients, 14 well-controlled DM patients (hemoglobin A1c [HbA1c] <7.0%), and 37 poorly controlled DM patients (HbA1c ≥7%) who underwent virtual histology intravascular ultrasound (VH-IVUS) examinations of culprit lesions. Results: The DM patients had longer lesion length (20.2 ± 7.8 mm vs 17.0 ± 7.3 mm; P≤.013) than non-DM patients. The plaque volume was highest in the poorly-controlled DM patients (188.9 ± 92.6 mm) compared with the non-DM patients (144.1 ± 92.3 mm; P≤.011) and the well-controlled DM patients (151.7 ± 82.4 mm; P≤.194). The well-controlled DM patients had less dense calcium (0.33 ± 0.14 mm/mm vs 0.71 ± 0.60 mm/mm; P≤.020) and less necrotic core (0.71 ± 0.48 mm/mm vs 1.30 ± 0.94 mm/mm; P≤.029) than the poorly-controlled DM patients and had similar amounts of dense calcium and necrotic core with non-DM patients, whereas fibrous and fibro-fatty volume showed no significant differences among the groups. Conclusion: Coronary plaque composition and plaque volume in well-controlled DM patients are similar to those in non-DM patients and both groups had less dense calcium and necrotic core volume than the poorly-controlled DM patients. These findings suggest hyperglycemia control is important in DM patients with angina.

AB - Background: Patients with diabetes mellitus (DM) are known to have large necrotic core in their coronary plaque compared to non-DM patients. We assessed coronary plaque composition in patients with angina and with/without DM according to glucose control. Methods: Study subjects consisted of 114 non-DM patients, 14 well-controlled DM patients (hemoglobin A1c [HbA1c] <7.0%), and 37 poorly controlled DM patients (HbA1c ≥7%) who underwent virtual histology intravascular ultrasound (VH-IVUS) examinations of culprit lesions. Results: The DM patients had longer lesion length (20.2 ± 7.8 mm vs 17.0 ± 7.3 mm; P≤.013) than non-DM patients. The plaque volume was highest in the poorly-controlled DM patients (188.9 ± 92.6 mm) compared with the non-DM patients (144.1 ± 92.3 mm; P≤.011) and the well-controlled DM patients (151.7 ± 82.4 mm; P≤.194). The well-controlled DM patients had less dense calcium (0.33 ± 0.14 mm/mm vs 0.71 ± 0.60 mm/mm; P≤.020) and less necrotic core (0.71 ± 0.48 mm/mm vs 1.30 ± 0.94 mm/mm; P≤.029) than the poorly-controlled DM patients and had similar amounts of dense calcium and necrotic core with non-DM patients, whereas fibrous and fibro-fatty volume showed no significant differences among the groups. Conclusion: Coronary plaque composition and plaque volume in well-controlled DM patients are similar to those in non-DM patients and both groups had less dense calcium and necrotic core volume than the poorly-controlled DM patients. These findings suggest hyperglycemia control is important in DM patients with angina.

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