The impact of drug shortages on patients with cardiovascular disease: Causes, consequences, and a call to action

Brent N. Reed, Erin R. Fox, Madeleine Konig, Cynthia A. Jackevicius, Frederick A. Masoudi, Alejandro A. Rabinstein, Robert L. Page

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Shortages of cardiovascular drugs have become increasingly common, representing an ongoing public health crisis. Given few therapeutic alternatives to many of the drugs in short supply, these shortages also pose a major challenge for cardiovascular care professionals. Although changes in the regulatory environment have led to some improvements in recent years, problems involving manufacturing processes remain the most common underlying cause. Because of the complex nature of drug shortages, sustainable solutions to prevent and mitigate them will require collaboration between regulatory agencies, drug manufacturers, and other key stakeholder groups. In this report, we describe the scope of the cardiovascular drug shortage crisis in the United States, including its underlying causes and the efforts currently being made to address it. Furthermore, we provide specific recommendations for how cardiovascular care professionals can be involved in efforts to limit the impact of drug shortages on patient care as well as policy changes aimed at preventing and mitigating them.

Original languageEnglish (US)
Pages (from-to)130-141
Number of pages12
JournalAmerican heart journal
Volume175
DOIs
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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