The impact of donor gender on cardiac peri-transplantation ischemia injury

Mohamad H. Yamani, Sabri K. Erinc, Ann McNeill, Norman B. Ratliff, Dianna Sendrey, Lingmei Zhou, Daniel J. Cook, Robert Hobbs, Gustavo Rincon, Corinne Bott-Silverman, James B. Young, Michael Banbury, Jose Navia, Nicholas Smedira, Randall C. Starling

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Cardiac allografts from female donors have been shown to be associated with increased risk of transplant vasculopathy. However, the influence of donor gender on peri-transplantation ischemic injury has not been evaluated. Methods: A total of 361 patients (mean age, 52 ± 10 years) underwent cardiac transplantation between January 1998 and December 2002. Patients were divided into 4 groups according to their donor-recipient gender status: Group A, male-male, 156; Group B, male-female, 37; Group C, female-male, 114; and Group D, female-female, 54. Serial right ventricular endomyocardial biopsy specimens were evaluated for ischemic injury during the first 4 weeks after transplantation. Results: Patients were similar in baseline characteristics. An increased incidence of ischemic injury complicated by fibrosis (12.9%, p = 0.03) and subsequent development of transplant vasculopathy (Kaplan-Meier 6-year freedom from vasculopathy, 53.4%; p = 0.012) was noted in Group D. No survival difference was observed among the 4 groups, however. In Group D (F-F), 2 patients underwent retransplantation and 2 patients underwent revascularization. Conclusions: The transplantation of a female cardiac allograft into a female recipient is associated with increased risk of ischemic injury complicated by fibrosis and subsequent transplant vasculopathy.

Original languageEnglish (US)
Pages (from-to)1741-1744
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume24
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Heart Transplantation
Ischemia
Tissue Donors
Wounds and Injuries
Transplantation
Transplants
Allografts
Fibrosis
Biopsy
Survival
Incidence

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Yamani, M. H., Erinc, S. K., McNeill, A., Ratliff, N. B., Sendrey, D., Zhou, L., ... Starling, R. C. (2005). The impact of donor gender on cardiac peri-transplantation ischemia injury. Journal of Heart and Lung Transplantation, 24(11), 1741-1744. https://doi.org/10.1016/j.healun.2005.02.022

The impact of donor gender on cardiac peri-transplantation ischemia injury. / Yamani, Mohamad H.; Erinc, Sabri K.; McNeill, Ann; Ratliff, Norman B.; Sendrey, Dianna; Zhou, Lingmei; Cook, Daniel J.; Hobbs, Robert; Rincon, Gustavo; Bott-Silverman, Corinne; Young, James B.; Banbury, Michael; Navia, Jose; Smedira, Nicholas; Starling, Randall C.

In: Journal of Heart and Lung Transplantation, Vol. 24, No. 11, 11.2005, p. 1741-1744.

Research output: Contribution to journalArticle

Yamani, MH, Erinc, SK, McNeill, A, Ratliff, NB, Sendrey, D, Zhou, L, Cook, DJ, Hobbs, R, Rincon, G, Bott-Silverman, C, Young, JB, Banbury, M, Navia, J, Smedira, N & Starling, RC 2005, 'The impact of donor gender on cardiac peri-transplantation ischemia injury', Journal of Heart and Lung Transplantation, vol. 24, no. 11, pp. 1741-1744. https://doi.org/10.1016/j.healun.2005.02.022
Yamani, Mohamad H. ; Erinc, Sabri K. ; McNeill, Ann ; Ratliff, Norman B. ; Sendrey, Dianna ; Zhou, Lingmei ; Cook, Daniel J. ; Hobbs, Robert ; Rincon, Gustavo ; Bott-Silverman, Corinne ; Young, James B. ; Banbury, Michael ; Navia, Jose ; Smedira, Nicholas ; Starling, Randall C. / The impact of donor gender on cardiac peri-transplantation ischemia injury. In: Journal of Heart and Lung Transplantation. 2005 ; Vol. 24, No. 11. pp. 1741-1744.
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abstract = "Background: Cardiac allografts from female donors have been shown to be associated with increased risk of transplant vasculopathy. However, the influence of donor gender on peri-transplantation ischemic injury has not been evaluated. Methods: A total of 361 patients (mean age, 52 ± 10 years) underwent cardiac transplantation between January 1998 and December 2002. Patients were divided into 4 groups according to their donor-recipient gender status: Group A, male-male, 156; Group B, male-female, 37; Group C, female-male, 114; and Group D, female-female, 54. Serial right ventricular endomyocardial biopsy specimens were evaluated for ischemic injury during the first 4 weeks after transplantation. Results: Patients were similar in baseline characteristics. An increased incidence of ischemic injury complicated by fibrosis (12.9{\%}, p = 0.03) and subsequent development of transplant vasculopathy (Kaplan-Meier 6-year freedom from vasculopathy, 53.4{\%}; p = 0.012) was noted in Group D. No survival difference was observed among the 4 groups, however. In Group D (F-F), 2 patients underwent retransplantation and 2 patients underwent revascularization. Conclusions: The transplantation of a female cardiac allograft into a female recipient is associated with increased risk of ischemic injury complicated by fibrosis and subsequent transplant vasculopathy.",
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AU - Yamani, Mohamad H.

AU - Erinc, Sabri K.

AU - McNeill, Ann

AU - Ratliff, Norman B.

AU - Sendrey, Dianna

AU - Zhou, Lingmei

AU - Cook, Daniel J.

AU - Hobbs, Robert

AU - Rincon, Gustavo

AU - Bott-Silverman, Corinne

AU - Young, James B.

AU - Banbury, Michael

AU - Navia, Jose

AU - Smedira, Nicholas

AU - Starling, Randall C.

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N2 - Background: Cardiac allografts from female donors have been shown to be associated with increased risk of transplant vasculopathy. However, the influence of donor gender on peri-transplantation ischemic injury has not been evaluated. Methods: A total of 361 patients (mean age, 52 ± 10 years) underwent cardiac transplantation between January 1998 and December 2002. Patients were divided into 4 groups according to their donor-recipient gender status: Group A, male-male, 156; Group B, male-female, 37; Group C, female-male, 114; and Group D, female-female, 54. Serial right ventricular endomyocardial biopsy specimens were evaluated for ischemic injury during the first 4 weeks after transplantation. Results: Patients were similar in baseline characteristics. An increased incidence of ischemic injury complicated by fibrosis (12.9%, p = 0.03) and subsequent development of transplant vasculopathy (Kaplan-Meier 6-year freedom from vasculopathy, 53.4%; p = 0.012) was noted in Group D. No survival difference was observed among the 4 groups, however. In Group D (F-F), 2 patients underwent retransplantation and 2 patients underwent revascularization. Conclusions: The transplantation of a female cardiac allograft into a female recipient is associated with increased risk of ischemic injury complicated by fibrosis and subsequent transplant vasculopathy.

AB - Background: Cardiac allografts from female donors have been shown to be associated with increased risk of transplant vasculopathy. However, the influence of donor gender on peri-transplantation ischemic injury has not been evaluated. Methods: A total of 361 patients (mean age, 52 ± 10 years) underwent cardiac transplantation between January 1998 and December 2002. Patients were divided into 4 groups according to their donor-recipient gender status: Group A, male-male, 156; Group B, male-female, 37; Group C, female-male, 114; and Group D, female-female, 54. Serial right ventricular endomyocardial biopsy specimens were evaluated for ischemic injury during the first 4 weeks after transplantation. Results: Patients were similar in baseline characteristics. An increased incidence of ischemic injury complicated by fibrosis (12.9%, p = 0.03) and subsequent development of transplant vasculopathy (Kaplan-Meier 6-year freedom from vasculopathy, 53.4%; p = 0.012) was noted in Group D. No survival difference was observed among the 4 groups, however. In Group D (F-F), 2 patients underwent retransplantation and 2 patients underwent revascularization. Conclusions: The transplantation of a female cardiac allograft into a female recipient is associated with increased risk of ischemic injury complicated by fibrosis and subsequent transplant vasculopathy.

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