The impact of donor gender on cardiac peri-transplantation ischemia injury

Mohamad H. Yamani, Sabri K. Erinc, Ann McNeill, Norman B. Ratliff, Dianna Sendrey, Lingmei Zhou, Daniel J. Cook, Robert Hobbs, Gustavo Rincon, Corinne Bott-Silverman, James B. Young, Michael Banbury, Jose Navia, Nicholas Smedira, Randall C. Starling

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Cardiac allografts from female donors have been shown to be associated with increased risk of transplant vasculopathy. However, the influence of donor gender on peri-transplantation ischemic injury has not been evaluated. Methods: A total of 361 patients (mean age, 52 ± 10 years) underwent cardiac transplantation between January 1998 and December 2002. Patients were divided into 4 groups according to their donor-recipient gender status: Group A, male-male, 156; Group B, male-female, 37; Group C, female-male, 114; and Group D, female-female, 54. Serial right ventricular endomyocardial biopsy specimens were evaluated for ischemic injury during the first 4 weeks after transplantation. Results: Patients were similar in baseline characteristics. An increased incidence of ischemic injury complicated by fibrosis (12.9%, p = 0.03) and subsequent development of transplant vasculopathy (Kaplan-Meier 6-year freedom from vasculopathy, 53.4%; p = 0.012) was noted in Group D. No survival difference was observed among the 4 groups, however. In Group D (F-F), 2 patients underwent retransplantation and 2 patients underwent revascularization. Conclusions: The transplantation of a female cardiac allograft into a female recipient is associated with increased risk of ischemic injury complicated by fibrosis and subsequent transplant vasculopathy.

Original languageEnglish (US)
Pages (from-to)1741-1744
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume24
Issue number11
DOIs
StatePublished - Nov 1 2005

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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    Yamani, M. H., Erinc, S. K., McNeill, A., Ratliff, N. B., Sendrey, D., Zhou, L., Cook, D. J., Hobbs, R., Rincon, G., Bott-Silverman, C., Young, J. B., Banbury, M., Navia, J., Smedira, N., & Starling, R. C. (2005). The impact of donor gender on cardiac peri-transplantation ischemia injury. Journal of Heart and Lung Transplantation, 24(11), 1741-1744. https://doi.org/10.1016/j.healun.2005.02.022