The impact of debulking surgery in patients with node-positive epithelial ovarian cancer: Analysis of prognostic factors related to overall survival and progression-free survival after an extended long-term follow-up period

Augusto Pereira, Tirso Pérez-Medina, Javier F. Magrina, Paul Magtibay, Ana Rodríguez-Tapia, Tatiana Cuesta-Guardiola, Irene Peregrin, Elsa Mendizabal, Santiago Lizarraga, Luís Ortiz-Quintana

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective to estimate the prognostic factors associated with survival and progression free survival (PFS) in patients with node-positive epithelial ovarian cancer (EOC) after an extended long-term follow-up period. Methods Data was provided by the Tumor Registry of the Mayo Clinic, Scottsdale, Arizona on 116 node-positive EOC patients who underwent primary cytoreductive surgery observed over the period 1996-2014. Results At censoring date, 21 patients were alive (18%), 95 dead (82%), 18 without evidence of disease (NED) (15 alive, 3 dead) and 76 with evidence of disease (ED) (2 alive, 74 dead). Twenty-nine ED patients (38.2%) experienced a recurrence within 2 years, 53 patients (69.7%) before 5 years. No recurrences were recorded after 10 years. The median follow-up in alive patients was 169.8 months (1.20-207.9 months), 34.9 months (0.30-196.2 months) in dead patients, 128.4 months for NED patients (72.8-202.5 months) and 34.6 months (0.1-106.9 months) in ED patients. Multivariate analysis showed an increased risk of dead in patients with age ≥60 years (HR: 3.20; p <0.002), stage IVA/B (compared with stage IIIA1/2, HR: 4.31; p <0.001 and stage IIIB/C, HR: 5.31; p <0.010) and incomplete surgery (compared with complete surgery, HR: 3.10; 95% CI, 1.41-6.77; p <0.003) and a decreased PFS in stage IVA/B (compared with stages IIIB/C; p = 0.003 and stage IIIA; p = 0.000) and residual volume after surgery >0.6 cm (compared with residual disease

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalSurgical Oncology
Volume25
Issue number1
DOIs
StatePublished - Mar 1 2016

Keywords

  • Extended long-term follow-up
  • Long-term follow up
  • Overall survival
  • Prognostic factors
  • Progression free survival

ASJC Scopus subject areas

  • Oncology
  • Surgery

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