The impact of alcohol consumption and cholecystectomy on small intestinal bacterial overgrowth

Scott L. Gabbard, Brian E. Lacy, Gary M. Levine, Michael D. Crowell

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background The etiology of small intestinal bacterial overgrowth (SIBO) is diverse and frequently multi-factorial. SIBO is thought to result from structural changes of the gastrointestinal tract, disordered peristalsis of the stomach and/or small intestine, or a disruption of the normal mucosal defenses of the small intestine. Alcoholics are reported to have higher rates of SIBO, as diagnosed by jejunal aspirate; however, no data are available on the association between moderate alcohol consumption and SIBO. Aim To evaluate the association between moderate alcohol consumption and SIBO and identify risk factors for SIBO using the lactulose breath test (LBT). Methods A retrospective chart review was completed for 210 consecutive patients who underwent the LBT between 2008 and 2010. We reviewed demographic data, including age, race, body mass index, alcohol and tobacco history, medication use, comorbid medical conditions, and history of abdominal surgery. Results The study included 196 patients (68 % female; mean age 55 years), 93 of whom had a positive LBT (47.4 %). Of those patients who consumed a moderate amount of alcohol, 58 % had a positive LBT, compared to 38.9 % of abstainers (P = 0.008). Those with a history of cholecystectomy had significantly lower rates of a positive LBT than those who had not (33.3 vs. 51.7 % respectively; P = 0.031). Neither proton pump inhibitor (PPI) use nor tobacco use was associated with a positive LBT. Conclusion In this retrospective review, moderate alcohol consumption was a strong risk factor for SIBO. Cholecystectomy appeared to be protective against SIBO. Neither PPI use nor tobacco use was associated with an increased risk of SIBO.

Original languageEnglish (US)
Pages (from-to)638-644
Number of pages7
JournalDigestive Diseases and Sciences
Volume59
Issue number3
DOIs
StatePublished - Mar 2014

Fingerprint

Lactulose
Breath Tests
Cholecystectomy
Alcohol Drinking
Proton Pump Inhibitors
Tobacco Use
Small Intestine
Alcohols
Peristalsis
Alcoholics
Tobacco
Gastrointestinal Tract
Stomach
Body Mass Index
History
Demography

Keywords

  • Alcohol
  • Cholecystectomy
  • Irritable bowel syndrome
  • Lactulose breath test
  • Proton pump inhibitor
  • Small intestinal bacterial overgrowth

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

The impact of alcohol consumption and cholecystectomy on small intestinal bacterial overgrowth. / Gabbard, Scott L.; Lacy, Brian E.; Levine, Gary M.; Crowell, Michael D.

In: Digestive Diseases and Sciences, Vol. 59, No. 3, 03.2014, p. 638-644.

Research output: Contribution to journalArticle

Gabbard, Scott L. ; Lacy, Brian E. ; Levine, Gary M. ; Crowell, Michael D. / The impact of alcohol consumption and cholecystectomy on small intestinal bacterial overgrowth. In: Digestive Diseases and Sciences. 2014 ; Vol. 59, No. 3. pp. 638-644.
@article{ecb0cf2ca77242e6abba1490f6d2d2e7,
title = "The impact of alcohol consumption and cholecystectomy on small intestinal bacterial overgrowth",
abstract = "Background The etiology of small intestinal bacterial overgrowth (SIBO) is diverse and frequently multi-factorial. SIBO is thought to result from structural changes of the gastrointestinal tract, disordered peristalsis of the stomach and/or small intestine, or a disruption of the normal mucosal defenses of the small intestine. Alcoholics are reported to have higher rates of SIBO, as diagnosed by jejunal aspirate; however, no data are available on the association between moderate alcohol consumption and SIBO. Aim To evaluate the association between moderate alcohol consumption and SIBO and identify risk factors for SIBO using the lactulose breath test (LBT). Methods A retrospective chart review was completed for 210 consecutive patients who underwent the LBT between 2008 and 2010. We reviewed demographic data, including age, race, body mass index, alcohol and tobacco history, medication use, comorbid medical conditions, and history of abdominal surgery. Results The study included 196 patients (68 {\%} female; mean age 55 years), 93 of whom had a positive LBT (47.4 {\%}). Of those patients who consumed a moderate amount of alcohol, 58 {\%} had a positive LBT, compared to 38.9 {\%} of abstainers (P = 0.008). Those with a history of cholecystectomy had significantly lower rates of a positive LBT than those who had not (33.3 vs. 51.7 {\%} respectively; P = 0.031). Neither proton pump inhibitor (PPI) use nor tobacco use was associated with a positive LBT. Conclusion In this retrospective review, moderate alcohol consumption was a strong risk factor for SIBO. Cholecystectomy appeared to be protective against SIBO. Neither PPI use nor tobacco use was associated with an increased risk of SIBO.",
keywords = "Alcohol, Cholecystectomy, Irritable bowel syndrome, Lactulose breath test, Proton pump inhibitor, Small intestinal bacterial overgrowth",
author = "Gabbard, {Scott L.} and Lacy, {Brian E.} and Levine, {Gary M.} and Crowell, {Michael D.}",
year = "2014",
month = "3",
doi = "10.1007/s10620-013-2960-y",
language = "English (US)",
volume = "59",
pages = "638--644",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - The impact of alcohol consumption and cholecystectomy on small intestinal bacterial overgrowth

AU - Gabbard, Scott L.

AU - Lacy, Brian E.

AU - Levine, Gary M.

AU - Crowell, Michael D.

PY - 2014/3

Y1 - 2014/3

N2 - Background The etiology of small intestinal bacterial overgrowth (SIBO) is diverse and frequently multi-factorial. SIBO is thought to result from structural changes of the gastrointestinal tract, disordered peristalsis of the stomach and/or small intestine, or a disruption of the normal mucosal defenses of the small intestine. Alcoholics are reported to have higher rates of SIBO, as diagnosed by jejunal aspirate; however, no data are available on the association between moderate alcohol consumption and SIBO. Aim To evaluate the association between moderate alcohol consumption and SIBO and identify risk factors for SIBO using the lactulose breath test (LBT). Methods A retrospective chart review was completed for 210 consecutive patients who underwent the LBT between 2008 and 2010. We reviewed demographic data, including age, race, body mass index, alcohol and tobacco history, medication use, comorbid medical conditions, and history of abdominal surgery. Results The study included 196 patients (68 % female; mean age 55 years), 93 of whom had a positive LBT (47.4 %). Of those patients who consumed a moderate amount of alcohol, 58 % had a positive LBT, compared to 38.9 % of abstainers (P = 0.008). Those with a history of cholecystectomy had significantly lower rates of a positive LBT than those who had not (33.3 vs. 51.7 % respectively; P = 0.031). Neither proton pump inhibitor (PPI) use nor tobacco use was associated with a positive LBT. Conclusion In this retrospective review, moderate alcohol consumption was a strong risk factor for SIBO. Cholecystectomy appeared to be protective against SIBO. Neither PPI use nor tobacco use was associated with an increased risk of SIBO.

AB - Background The etiology of small intestinal bacterial overgrowth (SIBO) is diverse and frequently multi-factorial. SIBO is thought to result from structural changes of the gastrointestinal tract, disordered peristalsis of the stomach and/or small intestine, or a disruption of the normal mucosal defenses of the small intestine. Alcoholics are reported to have higher rates of SIBO, as diagnosed by jejunal aspirate; however, no data are available on the association between moderate alcohol consumption and SIBO. Aim To evaluate the association between moderate alcohol consumption and SIBO and identify risk factors for SIBO using the lactulose breath test (LBT). Methods A retrospective chart review was completed for 210 consecutive patients who underwent the LBT between 2008 and 2010. We reviewed demographic data, including age, race, body mass index, alcohol and tobacco history, medication use, comorbid medical conditions, and history of abdominal surgery. Results The study included 196 patients (68 % female; mean age 55 years), 93 of whom had a positive LBT (47.4 %). Of those patients who consumed a moderate amount of alcohol, 58 % had a positive LBT, compared to 38.9 % of abstainers (P = 0.008). Those with a history of cholecystectomy had significantly lower rates of a positive LBT than those who had not (33.3 vs. 51.7 % respectively; P = 0.031). Neither proton pump inhibitor (PPI) use nor tobacco use was associated with a positive LBT. Conclusion In this retrospective review, moderate alcohol consumption was a strong risk factor for SIBO. Cholecystectomy appeared to be protective against SIBO. Neither PPI use nor tobacco use was associated with an increased risk of SIBO.

KW - Alcohol

KW - Cholecystectomy

KW - Irritable bowel syndrome

KW - Lactulose breath test

KW - Proton pump inhibitor

KW - Small intestinal bacterial overgrowth

UR - http://www.scopus.com/inward/record.url?scp=84896731920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896731920&partnerID=8YFLogxK

U2 - 10.1007/s10620-013-2960-y

DO - 10.1007/s10620-013-2960-y

M3 - Article

C2 - 24323179

AN - SCOPUS:84896731920

VL - 59

SP - 638

EP - 644

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 3

ER -