The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension

J. Balding, W. J. Livingstone, Sean J Pittock, L. Mynett-Johnson, T. Ahern, Owen P. Smith

Research output: Contribution to journalArticle

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Abstract

Background: Recent data suggest that inflammatory reactions are involved in the pathogenesis of cerebral ischaemia. Aim: To investigate whether certain inflammatory genetic polymorphisms are associated with the occurrence of ischaemic stroke. Methods: We investigated the prevalence of six polymorphisms in cytokine genes (IL-6, TNF-α, TNF-β, IL-β, IL-10, and IL-1Rα) in a group of ischaemic stroke patients (n=105) and in a control population (n=389). We analysed the prevalence of these polymorphisms in different stroke subtypes and in relation to outcome six months post-stroke. Results: There was no significant variation in cytokine gene polymorphism frequencies between control and stroke populations or for different stroke subtypes. Subgroup analysis demonstrated that the prevalence of the IL-6 -174 CC genotype was significantly lower in stroke patients without a history of hypertension compared to controls. Conclusion: The IL6 -174 CC genotype may be protective against stroke in those patients who have no history of hypertension. Further studies are required to verify these findings.

Original languageEnglish (US)
Pages (from-to)200-203
Number of pages4
JournalIrish Journal of Medical Science
Volume173
Issue number4
StatePublished - Oct 2004
Externally publishedYes

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Interleukin-6
Stroke
Hypertension
Genotype
Cytokines
Genetic Polymorphisms
Brain Ischemia
Gene Frequency
Interleukin-10
Population
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Balding, J., Livingstone, W. J., Pittock, S. J., Mynett-Johnson, L., Ahern, T., & Smith, O. P. (2004). The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension. Irish Journal of Medical Science, 173(4), 200-203.

The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension. / Balding, J.; Livingstone, W. J.; Pittock, Sean J; Mynett-Johnson, L.; Ahern, T.; Smith, Owen P.

In: Irish Journal of Medical Science, Vol. 173, No. 4, 10.2004, p. 200-203.

Research output: Contribution to journalArticle

Balding, J, Livingstone, WJ, Pittock, SJ, Mynett-Johnson, L, Ahern, T & Smith, OP 2004, 'The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension', Irish Journal of Medical Science, vol. 173, no. 4, pp. 200-203.
Balding, J. ; Livingstone, W. J. ; Pittock, Sean J ; Mynett-Johnson, L. ; Ahern, T. ; Smith, Owen P. / The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension. In: Irish Journal of Medical Science. 2004 ; Vol. 173, No. 4. pp. 200-203.
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AU - Ahern, T.

AU - Smith, Owen P.

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