The IGF-p53 connection in cancer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

Original languageEnglish (US)
JournalGrowth Hormone and IGF Research
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Somatomedins
Apoptosis
Cell Cycle Checkpoints
Tumor Suppressor Genes
Oncogenes
Neoplasms
Carcinogenesis
Cell Death
Transcription Factors
Cell Proliferation
Mutation
Growth

Keywords

  • IGF
  • IGFBP-3
  • P53
  • PAPP-A
  • Tumor suppressor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The IGF-p53 connection in cancer. / Conover, Cheryl A.

In: Growth Hormone and IGF Research, 01.01.2017.

Research output: Contribution to journalArticle

@article{fc10a73c853d4505876ce37dd6cfb040,
title = "The IGF-p53 connection in cancer",
abstract = "Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.",
keywords = "IGF, IGFBP-3, P53, PAPP-A, Tumor suppressor",
author = "Conover, {Cheryl A}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.ghir.2017.11.007",
language = "English (US)",
journal = "Endocrinology and Metabolism, Supplement",
issn = "1096-6374",
publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - The IGF-p53 connection in cancer

AU - Conover, Cheryl A

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

AB - Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

KW - IGF

KW - IGFBP-3

KW - P53

KW - PAPP-A

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=85038621255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038621255&partnerID=8YFLogxK

U2 - 10.1016/j.ghir.2017.11.007

DO - 10.1016/j.ghir.2017.11.007

M3 - Article

JO - Endocrinology and Metabolism, Supplement

JF - Endocrinology and Metabolism, Supplement

SN - 1096-6374

ER -