Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.
|Original language||English (US)|
|Number of pages||4|
|Journal||Growth Hormone and IGF Research|
|State||Published - Apr 2018|
- Tumor suppressor
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism