The IGF-p53 connection in cancer

Cheryl A. Conover

doi:10.1016/j.ghir.2017.11.007

The IGF-p53 connection in cancer

Cheryl A. Conover

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	Growth Hormone and IGF Research
Volume	39
DOIs	https://doi.org/10.1016/j.ghir.2017.11.007
State	Published - Apr 2018

Keywords

IGF
IGFBP-3
PAPP-A
Tumor suppressor
p53

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ghir.2017.11.007

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title = "The IGF-p53 connection in cancer",

abstract = "Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.",

keywords = "IGF, IGFBP-3, PAPP-A, Tumor suppressor, p53",

author = "Conover, {Cheryl A.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2018",

month = apr,

doi = "10.1016/j.ghir.2017.11.007",

language = "English (US)",

volume = "39",

pages = "25--28",

journal = "Growth Hormone and IGF Research",

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T1 - The IGF-p53 connection in cancer

AU - Conover, Cheryl A.

PY - 2018/4

Y1 - 2018/4

N2 - Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

AB - Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

KW - IGF

KW - IGFBP-3

KW - PAPP-A

KW - Tumor suppressor

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=85038621255&partnerID=8YFLogxK

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U2 - 10.1016/j.ghir.2017.11.007

DO - 10.1016/j.ghir.2017.11.007

M3 - Short survey

C2 - 29273484

AN - SCOPUS:85038621255

SN - 1096-6374

VL - 39

SP - 25

EP - 28

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

ER -

The IGF-p53 connection in cancer

Abstract

Keywords

ASJC Scopus subject areas

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