The IGF-p53 connection in cancer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

Original languageEnglish (US)
JournalGrowth Hormone and IGF Research
DOIs
StateAccepted/In press - Jan 1 2017

Keywords

  • IGF
  • IGFBP-3
  • P53
  • PAPP-A
  • Tumor suppressor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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