The IDDM13 region containing the insulin-like growth factor binding protein-5 (IGFBP5) gene on chromosome 2q33-q36 and the genetic susceptibility to rheumatoid arthritis

S. L. Slager, L. Carleu, W. K. Chung, T. Jackson, R. J. Winchester, S. E. Hodge, P. S. Gulko

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Abstract

We considered that the constitutive over-expression by cultured rheumatoid arthritis (RA) fibroblast-lineage synoviocytes of genes like IGFBP5 could indicate new candidate susceptibility genes. IGFBP5 is located in a region where an insulin-dependent diabetes mellitus (IDDM) susceptibility locus, IDDM13 (2q33-q36), has been mapped. Previous evidence that non-MHC IDDM loci overlap RA susceptibility loci made IGFBP5 and its region an interesting candidate locus which was tested for linkage. Forty-nine sibships (2-4 affected siblings per sibship) with RA were genotyped with microsatellite markers covering an 11.2 cM interval in the IGFBP5/IDDM13 region. Both the two-point LOD scores and a 'nonparametric' allele-sharing analysis revealed no evidence for linkage (max LOD = 0.54, P = 0.5, respectively). Adjustments for the presence of 'shared-epitope' alleles did not significantly change the LOD scores. These results suggest that, despite the involvement of the 2q33-q36 chromosomal region in another organ-specific autoimmune disease, it is unlikely that this region harbors a RA susceptibility locus.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalGenes and Immunity
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2002

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Keywords

  • Autoimmune diseases
  • Complex traits
  • Linkage analysis
  • Non-MHC genes

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

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